Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/disclosure-of-interest/ and declare: support from the First Cut competition and the postgraduate medical education committee at McMaster University for the submitted work. GSC is a National Institute for Health and Care Research (NIHR) Senior Investigator. The views expressed in this article are those of the author(s) and not necessarily those of the NIHR, or the Department of Health and Social Care; AJT has received funding from HealthSense to investigate evidence based medicine applications of large language models. PM is the co-founder of BrainX; AS has received research funding from the Australian government and is co-founder of BantingMed Pty; DS is the acting deputy editor for The Lancet Digital Health; MM has received research funding from the Hospital Research Founding Group; TF sits on the executive committee of MDEpiNet; HF is a senior executive editor for The Lancet; CL is editor-in-chief of Annals of Internal Medicine; AF is executive managing editor and vice president, editorial operations, at JAMA and the JAMA Network; TF and EL are journal editors for The BMJ; RA is the editor-in-chief of the International Journal of Surgery; GS is an executive editor of Artificial Intelligence in Medicine; SL is a paid consultant for Astellas; DP has received research funding from the Italian Ministry of University and Research; MO is a paid consultant for Theator; TA, POV, and GG are board member of the MAGIC Evidence Ecosystem Foundation (www.magicproject.org), a non-for profit organisation that conducts research and evidence appraisal and guideline methodology and implementation, and provides authoring and publication software (MAGICapp) for evidence summaries, guidelines, and decision aids.