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Comment
. 2025 Sep;64(9):1425-1427.
doi: 10.1007/s40262-025-01554-9. Epub 2025 Aug 1.

Comment on "Understanding Voriconazole Metabolism: A Middle-Out Physiologically-Based Pharmacokinetic Modelling Framework Integrating In Vitro and Clinical Insights"

Nuala A Helsby  1 , Jacqueline A Hannam  2
Affiliations
Comment

Comment on "Understanding Voriconazole Metabolism: A Middle-Out Physiologically-Based Pharmacokinetic Modelling Framework Integrating In Vitro and Clinical Insights"

Nuala A Helsby et al. Clin Pharmacokinet. 2025 Sep.
No abstract available

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Conflict of interest statement

Declarations. Funding: No funding was received for the preparation of this letter. Data availability: Not applicable. Conflicts of Interest/Competing Interests: Nuala A. Helsby and Jacqueline A. Hannam have no conflicts of interest that are directly relevant to the content of this letter.

Comment on

References

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    1. Murayama N, Imai N, Nakane T, Shimizu M, Yamazaki H. Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes. Biochem Pharmacol. 2007;73(12):2020–6. - DOI - PubMed
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    1. Hohmann N, Kreuter R, Blank A, Weiss J, Burhenne J, Haefeli WE, et al. Autoinhibitory properties of the parent but not of the N-oxide metabolite contribute to infusion rate-dependent voriconazole pharmacokinetics. Br J Clin Pharmacol. 2017;83(9):1954–65. - DOI - PubMed - PMC

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