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. 2025 Aug 1.
doi: 10.1007/s13181-025-01092-7. Online ahead of print.

Patient Centered Outcomes Research in Medical Toxicology

Rachel Culbreth  1 , Maryann Mazer-Amirshahi  2 , Mark B Mycyk  3 , Alyssa Falise  4 , Jeffrey Brent  5   6 , Kim Aldy  4   7 , Paul Wax  4
Affiliations

Patient Centered Outcomes Research in Medical Toxicology

Rachel Culbreth et al. J Med Toxicol. .

Abstract

In recent years, medical toxicology research has evolved from relying heavily on case reports and case series to more rigorous methodologies, including randomized controlled trials and high-quality systematic reviews. Engaging patients as partners in research is increasingly recognized as a promising approach to generate evidence that is trusted, meaningful, and useful to clinicians, policymakers, as well as patients and community members. The American College of Medical Toxicology (ACMT) recently conducted a patient engagement project to promote meaningful research engagement with patients who have lived experiences with overdoses. This review intends to provide an overview of patient-centered outcomes research (PCOR) for the field of medical toxicology, which includes study design considerations, planning for recruitment of patients and stakeholders, and supporting sustainable partnerships.

Keywords: Community participation; Medical toxicology; Patient participation; Patient-centered outcomes research.

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Conflict of interest statement

Declarations. Conflict of interest: R. Culbreth, P. Wax, and J. Brent report PCORI funding support. The authors have no other conflicts of interest to disclose.

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