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Review
. 2025 Sep:88:107013.
doi: 10.1016/j.crad.2025.107013. Epub 2025 Jul 9.

Multilevel spinal lesions beyond metastases

Affiliations
Review

Multilevel spinal lesions beyond metastases

S L Chung et al. Clin Radiol. 2025 Sep.

Abstract

Aim: To review multi-level spinal lesions where metastasis was a possible differential diagnosis.

Materials: A series of anonymised patients who presented with multilevel spinal lesions were reviewed. Some patients presented with contiguous, multilevel, or diffuse spinal changes which ultimately proved to not be metastases despite initial suspicion. All these spinal lesions were evaluated with extensive imaging. If imaging features were suspicious for metastases or showed aggressive features, biopsy was performed. All data was anonymised.

Results: Despite not being metastases, some of these lesions can appear aggressive in nature. Differential diagnosis of multilevel spinal lesions included bone infarcts, Paget's, extra-medullary haematopoiesis, treatment related and axial spondyloarthropathy.

Conclusions: To help readers gain experience and confidence in assessing the differential diagnosis of multi-level spinal lesions which could be metastases.

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Conflict of interest statement

Conflict of interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Siok Li Chung reports writing assistance was provided by Princess Royal University Hospital. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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