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Review
. 2025 Sep;109(5):1029-1045.
doi: 10.1016/j.mcna.2025.02.010. Epub 2025 Apr 7.

Medication Safety in Acute Care Settings

Affiliations
Review

Medication Safety in Acute Care Settings

Eduard E Vasilevskis et al. Med Clin North Am. 2025 Sep.

Abstract

This article addresses medication-related problems (MRPs) in hospitals, which continue to cause substantial preventable harm. Medication errors (ME), adverse drug reactions, and adverse drug events remain prevalent, significantly impacting patient safety. The article highlights the importance of medication reconciliation, especially during care transitions, and the challenges posed by polypharmacy. It also explores technological advancements, such as clinical decision support systems and artificial intelligence, in reducing ME. Additionally, it examines the medication-related effects of emerging trends like the Hospital at Home model. The article underscores the need for continuous improvement in medication safety practices to reduce preventable harm.

Keywords: Adverse drug events; Clinical decision support; Drug intensification; Drug shortage; Medication discrepancies; Medication reconciliation; Medication safety; Polypharmacy.

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Conflict of interest statement

Disclosure Dr S. Kripalani has received support from Gilead Sciences, United States, Bayer, Germany, and Esperion Therapeutics, United States, unrelated to the present work. Dr E.E. Vasilevskis has received support from Gilead Sciences, unrelated to the present work. No other conflicts of interest to report.

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