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. 2025 Aug 2;15(1):28209.
doi: 10.1038/s41598-025-12908-5.

Echocardiographic assessment of left atrial structural and functional changes after catheter ablation in paroxysmal atrial fibrillation with preserved ejection fraction

Qi Zhang  1 , Nan Nan Liu  2 , Jing Shu Sun  1 , Zu Lu Wang  1 , Ming Liang  1 , Gui Shen Li  1 , Mei Yi Wang  1
Affiliations

Echocardiographic assessment of left atrial structural and functional changes after catheter ablation in paroxysmal atrial fibrillation with preserved ejection fraction

Qi Zhang et al. Sci Rep. .

Abstract

To evaluate dynamic changes in left atrial (LA) structure and function after catheter ablation in paroxysmal atrial fibrillation (PAF) patients with preserved ejection fraction using conventional echocardiography and 2D speckle-tracking imaging (2D-STI). Eighty-nine PAF patients underwent echocardiography at 48 h pre-ablation, 1-day, 1-month, and 3-month post-ablation. Parameters included LA diameter (LAD), volume index (LAVI), strain (left atrial systolic strain (LASRs), early left atrial diastolic strain (LASRe), late left atrial diastolic strain (LASRa), and stiffness (LASt). At 1 day post-ablation, left ventricular ejection fraction (LVEF), peak early LA diastolic strain (LASRe), peak late LA diastolic strain (LASRa), and their strain rates were lower than baseline, while LA ejection fraction (LAEF) was higher (all P < 0.05). At 1 month and 3 months post-ablation, LA diameter (LAD), end-systolic/diastolic volumes, and volume index (LAVI) were significantly reduced, while left atrial appendage flow velocity (LAA-V), LAEF, LVEF, peak LA systolic strain (LASRs), and related strain rates were increased (all P < 0.05). Cox regression analysis showed that the 1-month LASRs recovery rate (ΔLASRs) was an independent predictor of AF recurrence (hazard ratio = 0.72, 95% confidence interval: 0.54-0.96, P = 0.023). After catheter ablation, LA reverse remodeling exhibits a pattern of "functional recovery preceding structural recovery". The improvement in functional parameters at 1 month post-ablation is of significant value for predicting long-term prognosis.

Keywords: Catheter ablation; Echocardiography; Left atrium; Paroxysmal atrial fibrillation; Two-dimensional speckle tracking imaging.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests. Ethics approval: The study has been approved by the ethics committee of General Hospital of Northern Theater Command. All methods were performed in accordance with the relevant guidelines and regulations. Conflict of interest: The authors declare that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Left atrial end-diastolic volume (A) and left atrial end-systolic volume (B) before catheter ablation; Left atrial end-diastolic volume (C) and left atrial end-systolic volume (D) three months after catheter ablation.
Fig. 2
Fig. 2
left atrial strain (A) and strain rate (B) in the apical four-chamber view before catheter ablation; Left atrial strain (C) and strain rate (D) in the apical four-chamber view three months after catheter ablation.
See this image and copyright information in PMC

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