Dosing matters: DESTINY-CRC02 and the evolving treatment paradigm for HER2 positive colorectal cancer
- PMID: 40755731
- PMCID: PMC12314705
- DOI: 10.21037/tgh-25-7
Dosing matters: DESTINY-CRC02 and the evolving treatment paradigm for HER2 positive colorectal cancer
Keywords: Colorectal cancer (CRC); human epidermal growth factor receptor 2 (HER2); trastuzumab deruxtecan.
Conflict of interest statement
Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tgh.amegroups.com/article/view/10.21037/tgh-25-7/coif). O.B.A. reports research funding to institution: Taiho Oncology, Ipsen Pharmaceuticals, GSK, Bristol Myers Squibb, Boehringer Ingelheim, Xencor Inc., Cue Biopharma, Inc., Merck, Inhibitex Inc, and Arcus Biosciences Inc; consulting/advisory role: Ipsen Pharmaceuticals, GSK, Cue Biopharma, Inc., Abbvie, Taiho, Bristol Myers Squibb, AstraZeneca, Exelixis, Takeda, Boehringer Ingelheim, and Loxo Oncology; and involvement in Independent Data Monitoring Committee: Compass Therapeutics, Inc. The other author has no conflicts of interest to declare.
Comment on
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Trastuzumab deruxtecan in patients with HER2-positive advanced colorectal cancer (DESTINY-CRC02): primary results from a multicentre, randomised, phase 2 trial.Lancet Oncol. 2024 Sep;25(9):1147-1162. doi: 10.1016/S1470-2045(24)00380-2. Epub 2024 Aug 5. Lancet Oncol. 2024. PMID: 39116902 Clinical Trial.
References
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- Sartore-Bianchi A, Trusolino L, Martino C, et al. Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial. Lancet Oncol 2016;17:738-46. 10.1016/S1470-2045(16)00150-9 - DOI - PubMed
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