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Review
. 2025 Jul 30:18:2629-2639.
doi: 10.2147/DMSO.S507171. eCollection 2025.

Advances in the Epigenetic Mechanisms of Diabetic Nephropathy Pathogenesis

Changlong Zhang  1 , Song Xue  2 , Peijun Ren  1 , Shuaijie Han  2 , Yu Zhou  2 , Yingkui Si  2 , Xue Han  2 , Xiaoqian Zhang  2 , Yanan Zhang  2 , Na Chen  2 , Hua He  2 , Ran Feng  2 , Lili Shang  1   2
Affiliations
Review

Advances in the Epigenetic Mechanisms of Diabetic Nephropathy Pathogenesis

Changlong Zhang et al. Diabetes Metab Syndr Obes. .

Abstract

Diabetic nephropathy (DN) is one of the most severe microvascular complications of diabetes and a leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD). While traditional research has linked the onset of DN to factors such as metabolic dysregulation, inflammation, and oxidative stress, these mechanisms alone fail to fully explain the complex pathological features and individual variability of DN. In recent years, epigenetic research has provided new insights, revealing the critical roles of DNA methylation, histone modifications, and non-coding RNAs in the development of DN. DNA methylation regulates gene expression by altering methylation levels in promoter regions, affecting genes involved in inflammation and fibrosis. Histone modifications, including acetylation and methylation, influence gene transcription by altering chromatin structure. Additionally, non-coding RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), play essential roles in gene expression networks. This review summarizes the latest advances in understanding these epigenetic mechanisms in DN pathogenesis, explores their roles in regulating inflammation, fibrosis, and cell damage, and discusses their potential applications in the diagnosis and treatment of DN. Further investigation into epigenetic modifications holds promise for identifying novel diagnostic markers and personalized therapeutic strategies for DN.

Keywords: DNA methylation; diabetic nephropathy; epigenetics; histone modifications; non-coding RNAs.

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Conflict of interest statement

The authors declare that they have no competing interests in this work.

Figures

Figure 1
Figure 1
Epigenetic Regulation of Gene Expression.
Figure 2
Figure 2
Molecular Mechanism of DNA Methylation.
Figure 3
Figure 3
Three-dimensional Structure of Histones.
See this image and copyright information in PMC

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