Determination of Serum Levels of Interleukin-6 and the Trace Element Zinc According to the Clinical Status of Patients With COVID-19
- PMID: 40756075
- PMCID: PMC12316496
- DOI: 10.1155/ipid/6486467
Determination of Serum Levels of Interleukin-6 and the Trace Element Zinc According to the Clinical Status of Patients With COVID-19
Abstract
In the context of SARS-CoV-2 infection, the present study aimed to determine the clinical and laboratory characteristics and serum levels of IL-6 and zinc in patients with COVID-19 according to their clinical condition in a hospital in Lima, Peru. Patients were divided into 4 groups according to the clinical condition of the disease, the group of patients hospitalized in the intensive care unit, hospitalized patients who did not require intensive care unit, COVID-19 patients who did not require hospitalization, and a control group. It was determined that 64.8% of the patients evaluated were men. Patients hospitalized in the ICU were 11.25 times more likely to have a cough and 36.7 times more likely to have a fever compared to the control group. In the group of hospitalized patients who did not require ICU, the presence of cough was 9.44 times higher than in the control group. The lowest IL-6 values were obtained in the group of COVID-19 patients who did not require hospitalization (2 pg/mL) and the highest in the ICU group (168.5 pg/mL). On the other hand, the highest values of the micronutrient zinc were also obtained in the ICU group (3402.5 μg/dL). In this group, the highest values of lymphocytes, C-reactive protein, and lactate dehydrogenase were also found with statistical significance compared to the group of hospitalized patients who did not require ICU. In conclusion, patients with COVID-19 in the ICU had higher levels of IL-6 and zinc compared to the other groups. This group also had the highest levels of lymphocytes, C-reactive protein, and lactate dehydrogenase compared to the group of hospitalized patients who did not require ICU care.
Keywords: IL-6; SARS-CoV-2; cytokines; pandemic; zinc.
Copyright © 2025 Andrea Roman-Pimentel et al. Interdisciplinary Perspectives on Infectious Diseases published by John Wiley & Sons Ltd.
Conflict of interest statement
The authors declare no conflicts of interest.
Figures
Similar articles
-
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.Cochrane Database Syst Rev. 2022 May 20;5(5):CD013665. doi: 10.1002/14651858.CD013665.pub3. Cochrane Database Syst Rev. 2022. PMID: 35593186 Free PMC article.
-
Accuracy of routine laboratory tests to predict mortality and deterioration to severe or critical COVID-19 in people with SARS-CoV-2.Cochrane Database Syst Rev. 2024 Aug 6;8(8):CD015050. doi: 10.1002/14651858.CD015050.pub2. Cochrane Database Syst Rev. 2024. PMID: 39105481 Free PMC article.
-
AI Predictive Model of Mortality and Intensive Care Unit Admission in the COVID-19 Pandemic: Retrospective Population Cohort Study of 12,000 Patients.J Med Internet Res. 2025 Jul 10;27:e70674. doi: 10.2196/70674. J Med Internet Res. 2025. PMID: 40638909 Free PMC article.
-
Early intervention (mobilization or active exercise) for critically ill adults in the intensive care unit.Cochrane Database Syst Rev. 2018 Mar 27;3(3):CD010754. doi: 10.1002/14651858.CD010754.pub2. Cochrane Database Syst Rev. 2018. PMID: 29582429 Free PMC article.
-
The effect of sample site and collection procedure on identification of SARS-CoV-2 infection.Cochrane Database Syst Rev. 2024 Dec 16;12(12):CD014780. doi: 10.1002/14651858.CD014780. Cochrane Database Syst Rev. 2024. PMID: 39679851 Free PMC article.
References
-
- Kalaiselvan P., Yingchoncharoen P., Thongpiya J., Motes A., Nugent K. COVID-19 Infections and Inflammatory Markers in Patients Hospitalized During the First Year of the Pandemic. Journal of Primary Care & Community Health . 2023;14:p. 21501319231206911. doi: 10.1177/21501319231206911. - DOI - PMC - PubMed
Associated data
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous