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Comment
. 2025 Jul 18:16:1613147.
doi: 10.3389/fmicb.2025.1613147. eCollection 2025.

Commentary: Role of gut microbiota in infectious and inflammatory diseases

Gabriela Angélica Martínez-Nava  1 , Alberto López-Reyes  1 , Carlos Pineda  2
Affiliations
Comment

Commentary: Role of gut microbiota in infectious and inflammatory diseases

Gabriela Angélica Martínez-Nava et al. Front Microbiol. .
No abstract available

Keywords: gout; gut microbiota; hyperuricemia (HUA); inflammation; microbiome and dysbiosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Illustration showing the process of dysbiosis in the gut. Dysbiosis leads to the production of short-chain fatty acids (SCFAs) like acetate, butyrate, and propionate. Acetate crosses the intestinal barrier, influencing naive T-cells and macrophages. Interaction with macrophages through GPR43 and NLRP3 triggers IL-1β production. Naive T-cells differentiate into T-reg or Th17 cells, affecting inflammation. The diagram highlights pathways involving mTOR-S6K, STAT3, and others, leading to the release of cytokines IL-17, IL-21, and IL-26, illustrating inflammatory responses.
Figure 1
Schematic diagram of the microbiota-SCFA-immune axis in gout pathogenesis. Gut dysbiosis leads to altered SCFA production (notably acetate), which acts through GPR43 to promote IL-1β release in macrophages and Th17 differentiation in naïve T cells, fueling joint inflammation.
See this image and copyright information in PMC

Comment on

  • Role of gut microbiota in infectious and inflammatory diseases.
    Maciel-Fiuza MF, Muller GC, Campos DMS, do Socorro Silva Costa P, Peruzzo J, Bonamigo RR, Veit T, Vianna FSL. Maciel-Fiuza MF, et al. Front Microbiol. 2023 Mar 27;14:1098386. doi: 10.3389/fmicb.2023.1098386. eCollection 2023. Front Microbiol. 2023. PMID: 37051522 Free PMC article. Review.

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