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Comparative Study
. 1977 Jun;74(6):2551-5.
doi: 10.1073/pnas.74.6.2551.

Structural implications of sequence variability in immunoglobulins

E A Padlan
Comparative Study

Structural implications of sequence variability in immunoglobulins

E A Padlan. Proc Natl Acad Sci U S A. 1977 Jun.

Abstract

Immunoglobulin sequences were compared by using a technique that takes into account the dissimilarity in physicochemical properties of amino acids. Exterior residues showed greater structural variability than interior residues. High structural variability was found at positions known from crystallographic studies to be involved in hapten binding.

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References

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