Synthesis of Sialylgalactose Analogs via Fully α-Selective Sialylation
- PMID: 40758429
- DOI: 10.1093/bbb/zbaf117
Synthesis of Sialylgalactose Analogs via Fully α-Selective Sialylation
Abstract
A streamlined synthesis of sialylgalactose (NeuGal) analogs is described. Neuα(2,6)Gal and Neuα(2,3)Gal units were synthesized via fully α-selective sialylation of suitable Gal acceptors using a bicyclic sialyl donor. NeuGals were diversified through C5 amino group modification and sulfation, yielding NeuGal analogs with an amino linker for biological studies.
Keywords: glycosylation; sialic acid; sialoglycan.
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