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. 1977 Apr 29;52(2):119-22.
doi: 10.1007/BF00439097.

Morphine ingestion: genetic control in mice

G P Horowitz, G Whitney, J C Smith, F K Stephan

Morphine ingestion: genetic control in mice

G P Horowitz et al. Psychopharmacology (Berl). .

Abstract

C57BL/6J mice will drink large amounts of, and display a highly positive preference for, morphine sulfate when it is dissolved in an aqueous solution of sodium saccharin. In identical test situations DBA/2J mice will drink very little of, and display a strong avoidance toward, the morphine-saccharin solution. This clear separation between morphine-accepting and morphine-rejecting animals within a single species combined with a quick and simple method of inducing high levels of morphine ingestion could facilitate the discovery of causal factors in opiate addiction.

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References

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