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. 2025 Aug 4;25(1):1263.
doi: 10.1186/s12885-025-14705-9.

Breast cancer survival rates and determinants in Ethiopia: a systematic review and meta-analysis of longitudinal studies

Abenezer Melaku Tafese  1   2 , Meseker Tesfaye Fentie  3   4 , Beminate Lemma Seifu  5 , Angwach Abrham Asnake  6 , Bikiltu Dugassa Dirbaba  3 , Abdisa Gemedi Jara  7 , Elsabeth Tizazu Asare  8 , Brandon George  9   10
Affiliations

Breast cancer survival rates and determinants in Ethiopia: a systematic review and meta-analysis of longitudinal studies

Abenezer Melaku Tafese et al. BMC Cancer. .

Abstract

Background: Breast cancer is the most common cancer and the leading cause of cancer mortality among women in Ethiopia, accounting for 32% of new cancer cases and 17.6% of cancer deaths. Despite its growing burden, comprehensive data on survival rates and contributing factors remain limited. This systematic review and meta-analysis aimed to synthesize existing data on breast cancer survival in Ethiopia and identify key determinants influencing outcomes.

Methods: A comprehensive systematic search was conducted in PubMed, Web of Science, Scopus, Embase, and CINAHL to identify studies on breast cancer survival in Ethiopia published between January 2014 and August 2024. Eligible studies were screened and assessed for quality. A random-effects model was used to estimate pooled 1-, 3-, and 5-year survival rates and examine factors associated with survival.

Results: This review included 15 cohort studies with 6,232 breast cancer patients. The reported median age of patients ranged from 39.0 to 61.0 years, with median survival times varying between 10.0 and 58.7 months. Pooled 1-, 3-, and 5-year survival rates were 92.0% (95% CI: 85.0, 97.0), 66.0% (95% CI: 52.0, 78.0), and 22.0% (95% CI: 8.0, 40.0), respectively. Rural residence (AHR = 1.58, 95% CI: 1.15, 2.17), advanced-stage diagnosis (AHR = 2.56, 95% CI: 1.86, 3.52), and presence of comorbidity (AHR = 1.54, 95%CI: 1.20, 1.98) were associated with higher mortality, while initiation of hormonal therapy (AHR = 0.43, 95% CI: 0.30, 0.61) was associated with improved survival.

Conclusion: While short-term survival among breast cancer patients in Ethiopia is favorable, the 5-year survival rate remains significantly lower than regional and global estimates. Strengthening health system capacity and enhancing public awareness are critical to promoting early detection, ensuring timely treatment, and improving long-term outcomes.

Protocol registration: PROSPERO (CRD42024574529).

Supplementary Information: The online version contains supplementary material available at 10.1186/s12885-025-14705-9.

Keywords: Breast cancer; Ethiopia; Mortality; Prognostic factors; Survival.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram
Fig. 2
Fig. 2
Pooled adjusted hazard ratio for the effect of place of residence on breast cancer survival
Fig. 3
Fig. 3
Pooled adjusted hazard ratio for the effect of cancer stage on breast cancer survival
Fig. 4
Fig. 4
Pooled adjusted hazard ratio for the effect of hormonal therapy on breast cancer survival
Fig. 5
Fig. 5
Pooled adjusted hazard ratio for the effect of comorbidity on breast cancer survival
See this image and copyright information in PMC

References

    1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. 10.3322/caac.21660. - PubMed
    1. Arnold M, Morgan E, Rumgay H, et al. Current and future burden of breast cancer: global statistics for 2020 and 2040. Breast. 2022;66:15–23. 10.1016/j.breast.2022.08.010. - PMC - PubMed
    1. Lima SM, Kehm RD, Terry MB. Global breast cancer incidence and mortality trends by region, age-groups, and fertility patterns. EClinicalMedicine. 2021;38:100985. 10.1016/j.eclinm.2021.100985. - PMC - PubMed
    1. Ssentongo P, Lewcun JA, Candela X, et al. Regional, racial, gender, and tumor biology disparities in breast cancer survival rates in africa: A systematic review and meta-analysis. PLoS ONE. 2019;14(11):e0225039. 10.1371/journal.pone.0225039. - PMC - PubMed
    1. Francies FZ, Hull R, Khanyile R, Dlamini Z. Breast cancer in low-middle income countries: abnormality in splicing and lack of targeted treatment options. Am J Cancer Res. 2020;10(5):1568–91. - PMC - PubMed

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