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. 2025 Aug 5:9287329251363433.
doi: 10.1177/09287329251363433. Online ahead of print.

Technological advances in acupoint thread embedding treatment: Effects on NIHSS score, Serum SIRT1, HIF-1α, and macrophage efferocytosis in stroke patients

Min Li  1   2 , Wanyi Xie  1   2 , Qingrui Lv  1   2 , Meitang He  1   2 , Hanhong Zou  1   2 , Miaoying Hong  2 , Hanyan Pang  1   3 , Jingchao Cai  1   2 , Jianshuang Shi  1   2 , Wenhao Huang  1   2
Affiliations

Technological advances in acupoint thread embedding treatment: Effects on NIHSS score, Serum SIRT1, HIF-1α, and macrophage efferocytosis in stroke patients

Min Li et al. Technol Health Care. .

Expression of concern in

  • Expression of concern.
    [No authors listed] [No authors listed] Technol Health Care. 2025 Nov 12:9287329251392360. doi: 10.1177/09287329251392360. Online ahead of print. Technol Health Care. 2025. PMID: 41223024 No abstract available.

Abstract

BackgroundAcupoint thread embedding treatment (ATET) is a traditional therapeutic approach used in stroke rehabilitation.ObjectiveTo explore the application of ATET in combination with modern medical technology, examining its effects on neurological function and key serum biomarkers in stroke patients.MethodsA total of 108 stroke patients were randomly assigned to ATE treatment group (n = 52) and Control Group (n = 56). Various parameters including baseline characteristics, levels of inflammatory markers, macrophage efferocytosis-related factors, the National Institutes of Health Stroke Scale (NIHSS) scores, therapeutic efficacy, and adverse events were assessed and compared between the two groups.ResultsA significant improvement in NIHSS scores was observed in the treatment group compared to the control group. Additionally, serum levels of SIRT1, HIF-1α, and macrophage efferocytosis-related factors were significantly altered, suggesting that ATET may influence biological pathways involved in stroke recovery.ConclusionThe application of ATET, supported by advanced diagnostic technologies, shows promising effects in stroke rehabilitation. This study highlights the potential for integrating traditional therapies with modern medicine to improve clinical outcomes in stroke patients.

Keywords: Acupoint thread embedding treatment; HIF-1α; NIHSS score; SIRT1; macrophage efferocytosis-related factors; stroke.

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