Comparison of isatuximab-pomalidomide-dexamethasone versus elotuzumab-pomalidomide-dexamethasone in relapsed/refractory multiple myeloma patients: a target trial emulation using real-world data

Enrica Antonia Martino¹, Annalisa Pitino², Massimo Offidani³, Roberta Della Pepa⁴, Alessandro Gozzetti⁵, Velia Bongarzoni⁶, Antonio Maroccia⁷, Valeria Amico⁸, Paola Stefanoni⁹, Elena Zamagni¹⁰, Sofia Terlizzi¹¹, Daniele Derudas¹², Salvatore Palmieri¹³, Rosario Bianco¹⁴, Concetta Conticello¹⁵, Marino Brunori¹⁶, Angela Rago¹⁷, Flavia Lotti¹⁸, Raffaele Fontana¹⁹, Nicola Sgherza²⁰, Elena Rossi²¹, Anna Maria Cafro²², Massimiliano Arangio Febbo²³, Angela Maria Quinto²⁴, Claudio Cerchione²⁵, Gloria Margiotta Casaluci²⁶, Annalisa Citro²⁷, Catello Califano²⁸, Renato Zambello²⁹, Silvia Mangiacavalli³⁰, Carmine Liberatore³¹, Gabriele Buda³², Claudio De Magistris³³, Angela Amendola³⁴, Ernesto Vigna¹, Antonella Bruzzese¹, Emiliano Barbieri³⁵, Micol Quaresima³⁶, Daniela Roccotelli³⁷, Francesca Farina³⁸, Jacopo Micozzi³⁹, Iolanda Donatella Vincelli⁴⁰, Giuseppe Tarantini⁴¹, Elisabetta Antonioli⁴², Sara Aquino⁴³, Alessandro Maggi⁴⁴, Alessandra Lombardo⁴⁵, Giuseppe Bertuglia⁴⁶, Anna Furlan⁴⁷, Anna Mele⁴⁸, Ombretta Annibali⁴⁹, Emilia Cotzia⁵⁰, Pietro Benvenuti⁵¹, Lorenzo De Paoli⁵², Gregorio Barilà⁵³, Sonia Morè³, Valerio De Stefano²¹, Francesco Di Raimondo¹⁵, Maria Teresa Petrucci³⁹, Niccolò Bolli³³, Pellegrino Musto⁵⁴, Antonino Neri⁵⁵, Fortunato Morabito⁵⁶, Giovanni Tripepi⁵⁷, Massimo Gentile⁵⁸

Affiliations

¹ Department of Onco-hematology, Hematology Unit, Azienda Ospedaliera Annunziata, Cosenza.
² Institute of Clinical Physiology (IFC-CNR), Rome.
³ Hematology Unit, AOU delle Marche, Ancona.
⁴ Department of Clinical Medicine and Surgery, University Federico II, Naples.
⁵ Department of Medicine, Surgery and Neurosciences, University of Siena Policlinico S Maria alle Scotte, Siena.
⁶ UOC of Hematology San Giovanni-Addolorata Hospital Rome.
⁷ Hematology Unit - Ospedale dell'Angelo Azienda ULSS n.3 Serenissima, Venezia Mestre.
⁸ UOSD Ematologia, AORN San Pio, Benevento.
⁹ Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo.
¹⁰ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy; Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna.
¹¹ Department of Hematology ASST Spedali Civili di Brescia, Brescia.
¹² Department of Hematology, Businco Hospital, Cagliari.
¹³ Hematology Unit, Ospedale Cardarelli, Napoli.
¹⁴ Hematology, Hospital "Sant'Anna e San Sebastiano", Caserta.
¹⁵ Division of Hematology, Azienda Policlinico-S. Marco, University of Catania, Catania.
¹⁶ Internal Medicine, Ospedale Santa Croce, Fano.
¹⁷ UOSD Ematologia ASL Roma 1, Rome.
¹⁸ Institute of Hematology, TMO Azienda Universitaria-Ospedaliera Santa Maria della Misericordia di Perugia, Perugia.
¹⁹ Hematology and Transplant Center, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno.
²⁰ Unit of Hematology and Stem Cell Transplantation, AOUC Policlinico, Bari.
²¹ Section of Hematology, Catholic University, Fondazione Policlinico Gemelli IRCCS, Rome.
²² Department of Hematology, GOM Niguarda Hospital, Milan.
²³ Onco Hematology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua.
²⁴ Haematology and Transplant Unit, IRCCS - Istituto Tumori "Giovanni Paolo II", Bari.
²⁵ Department of Hematology, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Forlì-Cesena.
²⁶ Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara.
²⁷ Hematology Unit, Legnano General Hospital, Legnano (Milan).
²⁸ Onco-Hematology Unit, "A. Tortora" Hospital, Pagani.
²⁹ Department of Medicine (DIMED), Hematology and Clinical Immunology, Padua University School of Medicine, Padova.
³⁰ Division of Hematology, IRCCS Fondazione Policlinico San Matteo, Pavia.
³¹ Hematology Unit, Department of Oncology and Hematology, Ospedale Santo Spirito, Pescara, Italy; Department of Medicine and Aging Sciences, University of Chieti-Pescara, Chieti.
³² Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa.
³³ Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan.
³⁴ Hematology Unit, Azienda Ospedaliera Regionale "San Carlo", Potenza.
³⁵ Hematology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena.
³⁶ Hematology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia.
³⁷ Department of Hematology and Bone Marrow Transplant, IRCSS Casa Sollievo Della Sofferenza, San Giovanni Rotondo.
³⁸ Hematology and BMT Unit, IRCCS Ospedale San Raffaele, Milan.
³⁹ Department of Translational and Precision Medicine, Hematology Azienda Policlinico Umberto I Sapienza University of Rome, Rome.
⁴⁰ Department of Hemato-Oncology and Radiotherapy, Hematology Unit, Great Metropolitan Hospital "Bianchi-Melacrino-Morelli", Reggio Calabria.
⁴¹ Hematology Unit, "Dimiccoli" Hospital, Barletta (BAT).
⁴² Haematology Unit Careggi University Hospital, Florence.
⁴³ Hematology and Hematopoietic Stem Cell Transplantation Unit, IRCCS Ospedale Policlinico San Martino, Genoa.
⁴⁴ Haematology, Ospedale G. Moscati, Taranto.
⁴⁵ Onco-hematology Unit Azienda Ospedaliera Santa Maria of Terni, Terni.
⁴⁶ Division of Hematology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, University of Torino, Torino.
⁴⁷ Division of Hematology Ospedale Ca' Foncello di Treviso, ASL 2, Treviso.
⁴⁸ Haematology, Ospedale Cardinale Panico, Tricase (Lecce).
⁴⁹ Hematology, stem cell transplantation, Fondazione Policlinico Universitario Campus Bio medico di Roma, Rome.
⁵⁰ Section of Hematology-Ospedale E. Muscatello Augusta, Siracusa.
⁵¹ Department of Medicine and Surgery, University of Insubria and Department of Oncology, ASST Sette Laghi, Ospedale di Circolo, Varese.
⁵² Division of Hematology, Ospedale Sant'Andrea, Vercelli.
⁵³ Hematology Unit, Ospedale San Bortolo, Vicenza.
⁵⁴ Department of Precision and Regenerative Medicine and Ionian Area, "Aldo Moro" University School of Medicine, Bari.
⁵⁵ Scientific Directorate, Azienda USL-IRCCS of Reggio Emilia, Reggio Emilia. antonino.neri@ausl.re.it.
⁵⁶ Gruppo Amici Dell'Ematologia Foundation-GrADE, Reggio Emilia.
⁵⁷ Institute of Clinical Physiology (IFC-CNR), Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension of Reggio Calabria, Reggio Calabria.
⁵⁸ Department of Onco-hematology, Hematology Unit, Azienda Ospedaliera Annunziata, Cosenza, Italy; Department of Pharmacy, Health and Nutritional Science, University of Calabria, Rende. massim.gentile@tiscali.it.

PMID: 40761134
PMCID: PMC12358792
DOI: 10.3324/haematol.2025.287325

Comparison of isatuximab-pomalidomide-dexamethasone versus elotuzumab-pomalidomide-dexamethasone in relapsed/refractory multiple myeloma patients: a target trial emulation using real-world data

Enrica Antonia Martino et al. Haematologica. 2025.

. 2025 Mar 6;110(8):1875-1881.

doi: 10.3324/haematol.2025.287325.

Authors

Affiliations

¹ Department of Onco-hematology, Hematology Unit, Azienda Ospedaliera Annunziata, Cosenza.
² Institute of Clinical Physiology (IFC-CNR), Rome.
³ Hematology Unit, AOU delle Marche, Ancona.
⁴ Department of Clinical Medicine and Surgery, University Federico II, Naples.
⁵ Department of Medicine, Surgery and Neurosciences, University of Siena Policlinico S Maria alle Scotte, Siena.
⁶ UOC of Hematology San Giovanni-Addolorata Hospital Rome.
⁷ Hematology Unit - Ospedale dell'Angelo Azienda ULSS n.3 Serenissima, Venezia Mestre.
⁸ UOSD Ematologia, AORN San Pio, Benevento.
⁹ Hematology and Bone Marrow Transplant Unit, ASST Papa Giovanni XXIII, Bergamo.
¹⁰ IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", Bologna, Italy; Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna.
¹¹ Department of Hematology ASST Spedali Civili di Brescia, Brescia.
¹² Department of Hematology, Businco Hospital, Cagliari.
¹³ Hematology Unit, Ospedale Cardarelli, Napoli.
¹⁴ Hematology, Hospital "Sant'Anna e San Sebastiano", Caserta.
¹⁵ Division of Hematology, Azienda Policlinico-S. Marco, University of Catania, Catania.
¹⁶ Internal Medicine, Ospedale Santa Croce, Fano.
¹⁷ UOSD Ematologia ASL Roma 1, Rome.
¹⁸ Institute of Hematology, TMO Azienda Universitaria-Ospedaliera Santa Maria della Misericordia di Perugia, Perugia.
¹⁹ Hematology and Transplant Center, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Salerno.
²⁰ Unit of Hematology and Stem Cell Transplantation, AOUC Policlinico, Bari.
²¹ Section of Hematology, Catholic University, Fondazione Policlinico Gemelli IRCCS, Rome.
²² Department of Hematology, GOM Niguarda Hospital, Milan.
²³ Onco Hematology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua.
²⁴ Haematology and Transplant Unit, IRCCS - Istituto Tumori "Giovanni Paolo II", Bari.
²⁵ Department of Hematology, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Forlì-Cesena.
²⁶ Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara.
²⁷ Hematology Unit, Legnano General Hospital, Legnano (Milan).
²⁸ Onco-Hematology Unit, "A. Tortora" Hospital, Pagani.
²⁹ Department of Medicine (DIMED), Hematology and Clinical Immunology, Padua University School of Medicine, Padova.
³⁰ Division of Hematology, IRCCS Fondazione Policlinico San Matteo, Pavia.
³¹ Hematology Unit, Department of Oncology and Hematology, Ospedale Santo Spirito, Pescara, Italy; Department of Medicine and Aging Sciences, University of Chieti-Pescara, Chieti.
³² Department of Clinical and Experimental Medicine, Hematology, University of Pisa, Pisa.
³³ Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan.
³⁴ Hematology Unit, Azienda Ospedaliera Regionale "San Carlo", Potenza.
³⁵ Hematology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena.
³⁶ Hematology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia.
³⁷ Department of Hematology and Bone Marrow Transplant, IRCSS Casa Sollievo Della Sofferenza, San Giovanni Rotondo.
³⁸ Hematology and BMT Unit, IRCCS Ospedale San Raffaele, Milan.
³⁹ Department of Translational and Precision Medicine, Hematology Azienda Policlinico Umberto I Sapienza University of Rome, Rome.
⁴⁰ Department of Hemato-Oncology and Radiotherapy, Hematology Unit, Great Metropolitan Hospital "Bianchi-Melacrino-Morelli", Reggio Calabria.
⁴¹ Hematology Unit, "Dimiccoli" Hospital, Barletta (BAT).
⁴² Haematology Unit Careggi University Hospital, Florence.
⁴³ Hematology and Hematopoietic Stem Cell Transplantation Unit, IRCCS Ospedale Policlinico San Martino, Genoa.
⁴⁴ Haematology, Ospedale G. Moscati, Taranto.
⁴⁵ Onco-hematology Unit Azienda Ospedaliera Santa Maria of Terni, Terni.
⁴⁶ Division of Hematology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, University of Torino, Torino.
⁴⁷ Division of Hematology Ospedale Ca' Foncello di Treviso, ASL 2, Treviso.
⁴⁸ Haematology, Ospedale Cardinale Panico, Tricase (Lecce).
⁴⁹ Hematology, stem cell transplantation, Fondazione Policlinico Universitario Campus Bio medico di Roma, Rome.
⁵⁰ Section of Hematology-Ospedale E. Muscatello Augusta, Siracusa.
⁵¹ Department of Medicine and Surgery, University of Insubria and Department of Oncology, ASST Sette Laghi, Ospedale di Circolo, Varese.
⁵² Division of Hematology, Ospedale Sant'Andrea, Vercelli.
⁵³ Hematology Unit, Ospedale San Bortolo, Vicenza.
⁵⁴ Department of Precision and Regenerative Medicine and Ionian Area, "Aldo Moro" University School of Medicine, Bari.
⁵⁵ Scientific Directorate, Azienda USL-IRCCS of Reggio Emilia, Reggio Emilia. antonino.neri@ausl.re.it.
⁵⁶ Gruppo Amici Dell'Ematologia Foundation-GrADE, Reggio Emilia.
⁵⁷ Institute of Clinical Physiology (IFC-CNR), Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension of Reggio Calabria, Reggio Calabria.
⁵⁸ Department of Onco-hematology, Hematology Unit, Azienda Ospedaliera Annunziata, Cosenza, Italy; Department of Pharmacy, Health and Nutritional Science, University of Calabria, Rende. massim.gentile@tiscali.it.

PMID: 40761134
PMCID: PMC12358792
DOI: 10.3324/haematol.2025.287325

No abstract available

PubMed Disclaimer

Figures

**Figure 1.**
**Kaplan-Meier survival curves for all 596 patients with relapsed/refractory multiple myeloma treated with isatuximab-pomalidomide-dexamethasone or elotuzumab-pomalidomide-dexamethasone.** (A, B) Kaplan-Meier curves of progression-free survival according to treatment arm in the original cohort (A) and in the weighted cohort (B). (C, D) Kaplan Meier curves of overall survival according to treatment arm in the original cohort (C) and in the weighted cohort (D). EloPd: elotuzumab, pomalidomide, dexamethasone; IsaPd: isatuximab, pomalidomide, dexamethasone; PFS: progression-free survival; OS: overall survival.

See this image and copyright information in PMC

References

1. Rajkumar SV. Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management. Am J Hematol. 2024;99(9):1802-1824. - PMC - PubMed
1. Dimopoulos MA, Dytfeld D, Grosicki S, et al. Elotuzumab plus pomalidomide and dexamethasone for multiple myeloma. N Engl J Med. 2018;379(19):1811-1822. - PubMed
1. Dimopoulos MA, Dytfeld D, Grosicki S, et al. Elotuzumab plus pomalidomide and dexamethasone for relapsed/refractory multiple myeloma: final overall survival analysis from the randomized phase II ELOQUENT-3 trial. J Clin Oncol. 2023;41(3):568-578. - PMC - PubMed
1. Attal M, Richardson PG, Rajkumar SV, et al. Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study. Lancet. 2019;394(10214):2072. - PubMed
1. Richardson PG, Perrot A, Miguel JS, et al. Isatuximabpomalidomide-dexamethasone versus pomalidomidedexamethasone in patients with relapsed and refractory multiple myeloma: final overall survival analysis. Haematologica. 2024;109(7):2239-2249. - PMC - PubMed

LinkOut - more resources

Full Text Sources
- Pagepress Publications
- PubMed Central

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Comparison of isatuximab-pomalidomide-dexamethasone versus elotuzumab-pomalidomide-dexamethasone in relapsed/refractory multiple myeloma patients: a target trial emulation using real-world data

Affiliations

Comparison of isatuximab-pomalidomide-dexamethasone versus elotuzumab-pomalidomide-dexamethasone in relapsed/refractory multiple myeloma patients: a target trial emulation using real-world data

Authors

Affiliations

Figures

References

LinkOut - more resources

Full Text Sources