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Review
. 2025 Jul 21:19:1607983.
doi: 10.3389/or.2025.1607983. eCollection 2025.

Mitophagy in the mechanisms of treatment resistance in solid tumors

Xiaoyi Yan  1 , Hui Ding  1 , Mengxiao Ren  1 , Lei Zang  1
Affiliations
Review

Mitophagy in the mechanisms of treatment resistance in solid tumors

Xiaoyi Yan et al. Oncol Rev. .

Abstract

This review aims to explore the mechanisms by which mitophagy contributes to treatment resistance in solid tumors. As advancements in cancer therapies continue to evolve, treatment resistance emerges as a significant barrier to successful tumor management. Mitophagy, a specific form of cellular autophagy, has been implicated in the survival, proliferation, and drug resistance of tumor cells. This article will summarize the latest research findings and analyze how mitophagy impacts the biological characteristics of solid tumors, thereby revealing its potential implications in cancer treatment strategies. By understanding the role of mitophagy in the context of treatment resistance, we may uncover new therapeutic targets and strategies to enhance the efficacy of existing cancer treatments.

Keywords: cellular autophagy; mitophagy; solid tumors; treatment resistance; tumor biology.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The unique role of mitophagy in different cancer treatment methods with dual effects.
See this image and copyright information in PMC

References

    1. Denisenko TV, Gogvadze V, Zhivotovsky B. Mitophagy in carcinogenesis and cancer treatment. Discover Oncol (2021) 12(1):58. 10.1007/s12672-021-00454-1 - DOI - PMC - PubMed
    1. Chen J, Zhou C, Yi J, Sun J, Xie B, Zhang Z, et al. Metformin and arsenic trioxide synergize to trigger Parkin/pink1-dependent mitophagic cell death in human cervical cancer HeLa cells. J Cancer (2021) 12(21):6310–9. 10.7150/jca.61299 - DOI - PMC - PubMed
    1. Pan B, Li Y, Han H, Zhang L, Hu X, Pan Y, et al. FoxG1/BNIP3 axis promotes mitophagy and blunts cisplatin resistance in osteosarcoma. Cancer Sci (2024) 115(8):2565–77. 10.1111/cas.16242 - DOI - PMC - PubMed
    1. Zheng B, Wang Y, Zhou B, Qian F, Liu D, Ye D, et al. Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages. J Adv Res (2025) 69:125–38. 10.1016/j.jare.2024.04.010 - DOI - PMC - PubMed
    1. Ahmadpour ST, Desquiret-Dumas V, Yikilmaz U, Dartier J, Domingo I, Wetterwald C, et al. Doxorubicin-induced autophagolysosome formation is partly prevented by mitochondrial ROS elimination in DOX-resistant breast cancer cells. Int J Mol Sci (2021) 22(17):9283. 10.3390/ijms22179283 - DOI - PMC - PubMed

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