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Case Reports
. 2025 Jul;80(7-8):529-533.

[The large cell anaplastic lymphoma associated with breast implants]

[Article in French]
Virginie Van Boeckel  1 , Ophélie Duysinx  1 , Karlien Vrancken  1 , Christophe Nizet  1 , Xavier Nelissen  1 , Jean-Luc Nizet  1
Affiliations
  • PMID: 40762342
Case Reports

[The large cell anaplastic lymphoma associated with breast implants]

[Article in French]
Virginie Van Boeckel et al. Rev Med Liege. 2025 Jul.

Abstract
in English, French

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare CD-30+/ALK- T-cell lymphoma. The combination of a textured breast implant, bacterial contamination and genetic predisposition appears to be necessary for the development of BIA-ALCL. The National Comprehensive Cancer Network (NCCN) has established guidelines for both diagnosis and treatment. Early detection of the disease is essential to ensure a cure. At an early stage and for the vast majority of patients, treatment consists of implant removal with associated total capsulectomy. We share our experience with the presentation of a case of BIA-ALCL discovered following the appearance of a periprosthetic seroma, 19 years after the fitting of breast implants.

Le lymphome anaplasique à grandes cellules associé aux implants mammaires (BIA-ALCL : Breast implant-associated anaplastic large cell lymphoma) est un lymphome rare à cellules T, CD-30+/ ALK-. La combinaison d’un implant mammaire texturé, d’une contamination bactérienne et d’une prédisposition génétique semble être nécessaire à l’apparition du BIA-ALCL. Le National Comprehensive Cancer Network (NCCN) a établi des lignes directrices pour le diagnostic et le traitement. Un dépistage rapide de la maladie est essentiel pour assurer la guérison. À un stade précoce et pour la grande majorité des patients, le traitement consiste à retirer l’implant avec une capsulectomie totale associée. Nous partageons notre expérience avec la présentation d’un cas de BIA-ALCL découvert suite à l’apparition d’un sérome péri-prothétique, 19 ans après la mise en place de prothèses mammaires.

Keywords: BIA-ALCL; Breast prosthesis; Lymphoma; Seroma.

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