Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis

Abstract

The regulation of energy homeostasis is an essential function of every living organism. In mammals a complex interplay of neural networks has evolved to ensure proper adaptation to energy demands, availability, consumption, storage and utilization. While a large set of parallel and redundant brain networks are functionally intertwined in these processes, a specific subset of hypothalamic neurons producing the agonist and antagonist of the anorectic signaling pathway controlled by the melanocortin receptor have been extensively studied. The anorectic/catabolic pro-opiomelanocortin (POMC) producing neurons and the orexigenic/anabolic Agouti-related peptide (AgRP) producing neurons exert opposing functions of various aspects of foraging, ingestive and post-ingestive processes. Located close to circumventricular these two populations integrate circulating reflecting energy status but are dynamically controlled by food-predicting cues. This review will be focusing on recent advances in understanding the role of the hypothalamic AgRP neurons, as critical metabolic sensors and regulators. We explore the intricate mechanisms by which these neurons integrate diverse nutritional signals and coordinate autonomic and behavioral responses to maintain metabolic equilibrium.

Keywords: AgRP; Feeding behavior; Metabolism; NPY; Obesity; POMC; Reward-dependent mechanisms.