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Practice Guideline
. 2025 Aug;23(8):284-291.
doi: 10.6004/jnccn.2025.0038.

NCCN Guidelines® Insights: Uterine Neoplasms, Version 3.2025

Nadeem R Abu-Rustum  1 , Susana M Campos  2 , Sudha Amarnath  3 , Rebecca Arend  4 , Emma Barber  5 , Kristin Bradley  6 , Rebecca Brooks  7 , Junzo Chino  8 , Hye Sook Chon  9 , Marta Ann Crispens  10 , Shari Damast  11 , Christine M Fisher  12 , Peter Frederick  13 , David K Gaffney  14 , Stephanie Gaillard  15 , Robert Giuntoli  16 , Scott Glaser  17 , Brooke E Howitt  18 , Lisa Landrum  19 , Jayanthi Lea  20 , Nita Lee  21 , Gina Mantia-Smaldone  22 , Andrea Mariani  23 , David Mutch  24 , Christa Nagel  25 , Larissa Nekhlyudov  2 , Karina Nieto  3 , Chika Nwachukwu  26 , Mirna Podoll  10 , Kerry Rodabaugh  27 , Ritu Salani  28 , John Schorge  29 , Scott Schuetze  30 , Jean Siedel  30 , Rachel Sisodia  31 , Pamela Soliman  32 , Stefanie Ueda  33 , Renata Urban  34 , Emily Wyse  35 , Nicole McMillian  36 , Vaishnavi Sambandam  36
Affiliations
Practice Guideline

NCCN Guidelines® Insights: Uterine Neoplasms, Version 3.2025

Nadeem R Abu-Rustum et al. J Natl Compr Canc Netw. 2025 Aug.

Abstract

The NCCN Guidelines for Uterine Neoplasms provide recommendations for diagnostic workup, clinical staging, and treatment options for patients with endometrial cancer and uterine sarcoma. The NCCN Cervical Uterine Panel meets at least annually to review comments from reviewers within their institutions; examine relevant new data from publications, abstracts, and recent FDA approvals; and reevaluate and update recommendations. These NCCN Guidelines Insights summarize the panel's deliberations on the new FIGO 2023 staging system and updates on the new systemic therapy recommendations for the management of endometrial cancer.

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