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Case Reports
. 2025 Aug 5;19(1):389.
doi: 10.1186/s13256-025-05246-7.

Targeting MET and KRAS G12C co-occurring mutation in metastatic adenoid cystic carcinoma of the trachea: a case report

Ling Zhang  1 , Tonghui Wang  2 , Yan Xu  1 , Youxin Ji  3 , Keke Nie  4
Affiliations
Case Reports

Targeting MET and KRAS G12C co-occurring mutation in metastatic adenoid cystic carcinoma of the trachea: a case report

Ling Zhang et al. J Med Case Rep. .

Abstract

Background: MET and KRAS comutation in the same group of cells of primary tracheal adenoid cystic carcinoma is extremely rare; there is no standard of care for patient with metastatic disease.

Case presentation: We report a 42-year-old treatment-naïve Chinese male patient with metastatic tracheal adenoid cystic carcinoma harboring a MET p.D1010Y and KRAS p.G12C comutation. The patient responded well to the MET inhibitor crizotinib and MEK inhibitor trametinib combination therapy, but had progression when he discontinued trametinib because of grade III rashes on the face and trunk. With the reintroduction of trametinib with a dose reduction, his metastatic lesions shrank after 2 months of therapy.

Conclusion: MET p.D1010Y and KRAS p.G12C comutation is extremely rare and could happen concurrently in the same group of cells of metastatic tracheal adenoid cystic carcinoma; crizotinib combined with trametinib is effective, and the toxicities are manageable.

Keywords: Adenoid cystic carcinoma; Case report; Gene mutation; Target therapy; Tracheal carcinoma.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital). Consent for publication: Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Competing interests: All authors declared there was no conflict of interest.

Figures

Fig. 1
Fig. 1
A–C Multiple metastasis nodules in both lungs (White arrow). D–F After 2 months of crizotinib and trametinib treatment, most of the nodules disappeared. G–I Reappearance and enlargement of previous metastatic nodules, as well new nodules, were found in both lungs and left pleura with crizotinib monotherapy (White arrow). J–L Lung metastatic lesions were shrunk, and partial response was achieved after rechallenged with trametinib combined with crizotinib (White arrow)
See this image and copyright information in PMC

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