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. 2025 Jul 17;12(8):ofaf415.
doi: 10.1093/ofid/ofaf415. eCollection 2025 Aug.

Comparison of Infection-Induced SARS-CoV-2 Seroprevalence Across Large-Scale Residual Samples From Blood Donors, Commercial Laboratories, and Health Checkups in Japan, 2023

Asuka Nishigaki  1   2 , Ryo Kinoshita  1 , Shoko Sakuraba  3 , Jun Sugihara  3 , Tadaki Suzuki  1 , Motoi Suzuki  1 , Daisuke Yoneoka  1
Affiliations

Comparison of Infection-Induced SARS-CoV-2 Seroprevalence Across Large-Scale Residual Samples From Blood Donors, Commercial Laboratories, and Health Checkups in Japan, 2023

Asuka Nishigaki et al. Open Forum Infect Dis. .

Abstract

We compared severe acute respiratory syndrome coronavirus 2 nucleocapsid antibody seroprevalence using 3 types of residual blood samples simultaneously collected in November-December 2023 from blood donors, commercial laboratories, and health checkups. Overall seroprevalence ranged from 53.5% to 58.8%, and notable variations were observed among the 30-39 and 50-59 age groups, highlighting the importance of multisource seroepidemiological surveillance.

Keywords: COVID-19; SARS-CoV-2; seroepidemiology; seroprevalence; surveillance.

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Conflict of interest statement

Potential conflicts of interest. All authors: no reported conflicts.

Figures

Figure 1.
Figure 1.
Comparison of infection-induced severe acute respiratory syndrome coronavirus 2 seroprevalence among blood donors, commercial laboratories, and health checkups. The analysis was limited to 15 prefectures with specimens available for all 3 sample populations. Seroprevalence estimates were adjusted for age and sex distribution in the population of each prefecture.
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