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. 2024 Oct 24;2(1):100034.
doi: 10.1016/j.bvth.2024.100034. eCollection 2025 Feb.

Podoplanin and microthrombi in lung injury

Jahnavi Gollamudi  1 , Ricardo Gonzalez Delgado  2 , Min Soon Cho  2 , Brianne Wharton  2 , Hani Lee  2 , Animesh Vadaparti  3 , Swapan K Dasgupta  4 , Miguel A Cruz  4 , Perumal Thiagarajan  4   5 , Vahid Afshar-Kharghan  2
Affiliations

Podoplanin and microthrombi in lung injury

Jahnavi Gollamudi et al. Blood Vessel Thromb Hemost. .
No abstract available

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
PDPN plasma level in patients with COVID-19. PDPN plasma levels and the severity of COVID-19 as defined by the National Institutes of Health criteria.
Figure 2.
Figure 2.
Expression of PDPN in the lung in COVID-19 pneumonia. Tissue specimens from the lungs of patients with COVID-19 pneumonia and patients without COVID-19 obtained during autopsy were examined. (A) Hematoxylin and eosin (H&E) and (B) immunohistochemistry stain for PDPN of the non–COVID-19 lung. Immunofluorescence staining of non–COVID-19 lungs with (C) lower original magnification (×100) and (D) higher original magnification (×200) showing few platelets in the lung parenchyma inside blood vessels (white arrowheads). (E) H&E and (F) immunohistochemistry stain for PDPN of COVID-19 lungs. Immunofluorescence staining of COVID-19 lungs at (G) lower original magnification (×100) and (H′-H′′) higher original magnification (×200). Platelets inside blood vessels are indicated with white arrowheads, and those colocalized with PDPN with yellow arrowheads. (I) Expressions of PDPN in COVID-19 and non–COVID-19 lungs are compared as mean fluorescence intensity (MFI) of immunofluorescence-stained slides. The box and whisker graph shows minimum to maximum values in each group (non–COVID-19: 182.5 ± 24.8, COVID-19: 261.7 ± 7.42; n = 4 images per group; P = .02, unpaired t test).
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