Inflammatory Association between Periodontal Disease and Systemic Health

Abstract

Periodontitis is an oral disease that affects almost half of the adult population in United States. The complex relationship between oral and systemic health has been the focus of extensive research, aiming to unravel the mechanisms linking periodontal disease with various systemic conditions. This systematic review provides an overview of recent findings on the interrelationship between periodontitis and various systemic diseases. Specifically, it explores the associations between periodontal disease and several systemic disorders, including cardiovascular diseases, respiratory conditions, endocrine abnormalities, musculoskeletal disorders, and reproductive system issues. The review comprehensively examines the latest evidence on the bidirectional interactions between these diseases. By integrating data from several studies, this review provides insights into the underlying mechanisms including inflammatory pathways and microbial interactions, connecting the oral and systemic health. Understanding these relationships is essential for all healthcare providers, including periodontists and medical physicians alike, as it aids in the development of comprehensive treatment approaches that consider both periodontal and systemic health interactions and effects. For healthcare providers this understanding of complex interactions and connections is crucial for identifying disease etiology, treatment planning and determining prognosis for their patients. This includes multidisciplinary approach that address both periodontal and systemic health. In conclusion, this systematic review enhances the existing body of knowledge by providing a comprehensive and up-to-date synthesis of the most recent data available on the periodontal-systemic health relationship. By highlighting current findings, this review not only underscores critical areas for future research but also identifies opportunities for meaningful clinical application.

Keywords: Arthritis; Cardiovascular health; Diabetes; Periodontal disease; Periodontitis; Pregnancy; Systemic conditions.