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. 2025 Aug 6:blood.2025029556.
doi: 10.1182/blood.2025029556. Online ahead of print.

Induction chemotherapy and molecular MRD influence outcomes in KMT2A-rearranged AML

Jad Othman  1 , Nicola Potter  2 , Sylvie D Freeman  3 , Nicholas McCarthy  3 , Jelena Jovanovic  4 , Manohursingh Runglall  5 , Joanna Canham  6 , Ian Thomas  6 , Sean Johnson  7 , Amanda Frances Gilkes  6 , James Durrell Cavenagh  8 , Panagiotis Kottaridis  9 , David C Taussig  10 , Claire Arnold  11 , Claire Jane Hemmaway Dr  12 , Dominic Culligan  13 , Ulrik Malthe Overgaard  14 , Mike Dennis  15 , Alan K Burnett  16 , Nigel H Russell  17 , Richard James Dillon  5
Affiliations

Induction chemotherapy and molecular MRD influence outcomes in KMT2A-rearranged AML

Jad Othman et al. Blood. .

Abstract

We analyzed 217 patients with KMT2A-rearranged AML in two large sequential randomized trials. Those randomized to FLAG-Ida had markedly lower rates of relapse than other chemotherapy regimens. Molecular MRD assessment after cycle two was strongly prognostic for relapse and death. AML17 ISRCTN55675535 AML19 ISRCTN78449203.

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