Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice

Takuya Karasawa¹, Ran Hee Choi², Cesar A Meza², Subhasmita Rout², Micah J Drummond³, Amandine Chaix⁴, Katsuhiko Funai⁵

Affiliations

¹ Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA; Department of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA; Research Institute for Sport Science, Nippon Sport Science University, Setagaya, Tokyo, Japan.
² Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA; Department of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
³ Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA; Department of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA; Department of Physical Therapy & Athletic Training, University of Utah, Salt Lake City, UT, USA; Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA.
⁴ Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA; Department of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA; Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA.
⁵ Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA; Department of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA; Department of Physical Therapy & Athletic Training, University of Utah, Salt Lake City, UT, USA; Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA. Electronic address: kfunai@utah.edu.

PMID: 40769122
DOI: 10.1016/j.cmet.2025.07.004

Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice

Takuya Karasawa et al. Cell Metab. 2025.

. 2025 Aug 5;37(8):1619-1620.

doi: 10.1016/j.cmet.2025.07.004.

Authors

Takuya Karasawa¹, Ran Hee Choi², Cesar A Meza², Subhasmita Rout², Micah J Drummond³, Amandine Chaix⁴, Katsuhiko Funai⁵

Affiliations

¹ Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA; Department of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA; Research Institute for Sport Science, Nippon Sport Science University, Setagaya, Tokyo, Japan.
² Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA; Department of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
³ Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA; Department of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA; Department of Physical Therapy & Athletic Training, University of Utah, Salt Lake City, UT, USA; Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA.
⁴ Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA; Department of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA; Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA.
⁵ Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA; Department of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA; Department of Physical Therapy & Athletic Training, University of Utah, Salt Lake City, UT, USA; Molecular Medicine Program, University of Utah, Salt Lake City, UT, USA. Electronic address: kfunai@utah.edu.

PMID: 40769122
DOI: 10.1016/j.cmet.2025.07.004

Abstract

Loss of lean mass is a potential concern for semaglutide-induced weight loss. This study indicates that semaglutide has unexpected effects on skeletal muscle mass and strength in mice, demonstrating a need to more carefully assess these effects in humans.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice

Affiliations

Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources