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. 2025 Aug 5;37(8):1630-1632.
doi: 10.1016/j.cmet.2025.06.005.

Insulin signaling in microglia: A metabolic switch controlling neuroinflammation and amyloid pathology in Alzheimer's disease

Eugenio Barone  1 , D Allan Butterfield  2
Affiliations

Insulin signaling in microglia: A metabolic switch controlling neuroinflammation and amyloid pathology in Alzheimer's disease

Eugenio Barone et al. Cell Metab. .

Abstract

Insulin resistance is a risk factor for Alzheimer's disease (AD). Chen et al.1 show that microglial insulin signaling is essential for metabolic homeostasis and immune regulation, while insulin resistance impairs Aβ clearance and promotes neuroinflammation in AD. Their findings reframe AD pathogenesis through a cell-type-specific lens.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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