Similar articles

• Toward Understanding the Mechanism of Client-Selective Small Molecule Inhibitors of the Sec61 Translocon.

  Sorout N, Helms V. Sorout N, et al. J Mol Recognit. 2025 Jan;38(1):e3108. doi: 10.1002/jmr.3108. Epub 2024 Oct 12. J Mol Recognit. 2025. PMID: 39394908 Free PMC article. Review.
• Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity.

  Lowe E, Anderl JL, Bade D, Delgado-Martin C, Dong C, Fan RA, Fang Y, Jiang J, Johnson HWB, Kempema A, McGilvray P, McMinn D, Millare B, Muchamuel T, Poweleit N, Qian Y, Rehan S, Scapin G, Sugahara A, Tranter D, Tuch B, Wang J, Wang L, Whang JA, Zuno-Mitchell P, Paavilainen VO, Park E, Taunton J, Kirk CJ, Anand NK. Lowe E, et al. J Pharmacol Exp Ther. 2025 Jun 14;392(8):103634. doi: 10.1016/j.jpet.2025.103634. Online ahead of print. J Pharmacol Exp Ther. 2025. PMID: 40669140
• Rough microsomes isolated from snap-frozen canine pancreatic tissue retain their co-translational translocation functionality.

  Croonenborghs M, Verhaegen M, Pauwels E, Provinciael B, Vermeire K. Croonenborghs M, et al. Biol Methods Protoc. 2025 Jun 2;10(1):bpaf044. doi: 10.1093/biomethods/bpaf044. eCollection 2025. Biol Methods Protoc. 2025. PMID: 40585179 Free PMC article.
• Exploring the ER channel protein Sec61: recent advances in pathophysiological significance and novel pharmacological inhibitors.

  Xin J, Yin K, Li S, Gu P, Shao S. Xin J, et al. Front Pharmacol. 2025 Jun 4;16:1580086. doi: 10.3389/fphar.2025.1580086. eCollection 2025. Front Pharmacol. 2025. PMID: 40535761 Free PMC article. Review.
• Single-molecule observations of human small heat shock proteins in complex with aggregation-prone client proteins.

  Rice L, Marzano N, Cox D, Skewes B, van Oijen AM, Ecroyd H. Rice L, et al. Biochem J. 2025 May 6;482(9):413-432. doi: 10.1042/BCJ20240473. Biochem J. 2025. PMID: 40241479 Free PMC article.