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Review
. 2025 Sep;59(1):47-75.
doi: 10.1016/j.yasu.2025.04.011. Epub 2025 Jun 12.

What Is the Role of Irreversible Electroporation for Pancreatic Cancer?

Robert C G Martin 2nd  1 , Christopher D Wilson  2
Affiliations
Review

What Is the Role of Irreversible Electroporation for Pancreatic Cancer?

Robert C G Martin 2nd et al. Adv Surg. 2025 Sep.

Abstract

Irreversible electroporation (IRE) has proven itself to be a viable surgical intervention for patients with borderline resectable pancreatic cancer and locally-advanced pancreatic cancer (LAPC). IRE has demonstrated encouraging survival and response outcomes when combined with induction chemotherapy versus patient populations that receive chemotherapy and/or chemo-radiation therapy alone. The optimal management of patients with LAPC is evolving quickly with the advent of improved IRE implementation. This article will present the current status of the role of IRE in patients with pancreatic cancer.

Keywords: Irreversible electroporation; Multi-disciplinary care; Optimal timing; Pancreatic adenocarcinoma; Patient selection.

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Conflict of interest statement

Disclosure R.C.G. Martin is a paid consultant for Angiodynamics, one of the manufactures of an IRE device, there are no other disclosures.

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