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. 2025 Aug 6;16(1):7252.
doi: 10.1038/s41467-025-62768-w.

Enzymatic craftsmanship in collagen glycosylation

Susovon Ghosh  1 , Dilip Kumar  2 , Bhaskar Mondal  3 , Trayambak Basak  4
Affiliations

Enzymatic craftsmanship in collagen glycosylation

Susovon Ghosh et al. Nat Commun. .

Abstract

Collagen IV, a key structural protein of basement membranes, is vital for the development and survival of multicellular life forms. Its maturation relies on specific post-translational O- glycosylation, primarily mediated by lysyl hydroxylase-3 (LH3) and other glycosyltransferases, which sculpt collagen by modifying the hydroxylysine residues with sugar moieties.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Multiscale collagen structure.
a Telopeptide and triple helical regions of collagen. b The sequential PTMs of collagen. c Quaternary ensemble of LH3 and GLT25D1,.
Fig. 2
Fig. 2. Secondary structures of LH3 and GLT25D1.
The active sites for the LH (top), GT (right), and GGT (bottom right) activity are presented in the inset.
See this image and copyright information in PMC

References

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