Relationship Between the Lactate-to-Albumin Ratio and 28-Day Overall Mortality in Critically Ill Patients with Pulmonary Embolism: A Retrospective Analysis of the MIMIC-IV Database

Abstract

BackgroundThe lactate-to-albumin ratio (LAR) has prognostic value in various clinical conditions, but its association with mortality in pulmonary embolism (PE) remains unclear. This study aims to investigate the relationship between LAR and 28-day all-cause mortality in PE patients.MethodsThis retrospective observational study used MIMIC-IV database, with 28-day mortality as the primary endpoint. Adjusted Cox models were used to assessed the LAR-mortality association, with subgroup analyses for stability. Kaplan-Meier curves estimated mortality across LAR tertiles. Restricted cubic spline(RCS) analysis evaluated nonlinearity. Receiver operating characteristic curves(ROC) and reclassification metrics were used to compare the predictive performance of LAR with the Pulmonary Embolism Severity Index (PESI).ResultsAmong the 319 included patients, 72 (22.6%) died within 28 days of admission. Non-survivors had significantly higher LAR levels. In adjusted Cox models, elevated LAR was independently associated with increased 28-day mortality risk. Kaplan-Meier curves showed significant survival differences across LAR tertiles. RCS analysis revealed a dose-response relationship with an inflection point around LAR 0.67. The ROC curve's C-statistic, validated by the DeLong test, highlights the superior performance of the LAR model, while the positive Integrated Discrimination Improvement and Net Reclassification Improvement values demonstrate its additional prognostic value over the PESI model. Subgroup analysis confirmed consistent findings across different patient groups.ConclusionElevated LAR was positively correlated with 28-day all-cause mortality in PE patients, maintaining prognostic value across subgroups. LAR showed potential as a practical prognostic indicator for PE risk stratification, warranting prospective validation and exploration of its clinical utility in PE management.

Keywords: MIMIC-IV database; lactate/Albumin ratio; mortality; prognosis; pulmonary embolism.

Figure 1.

Schematic Diagram of Study Sample Selection Steps. MIMIC, Medical Information Mart for Intensive Care; PE, Pulmonary Embolism; ICU, Intensive Care Unit.

Figure 2.

Kaplan-Meier Survival Analysis Curves for All-Cause Mortality Within 28-d of Hospitalization.

Figure 3.

RCS Curves for the Relationship Between LAR and 28-d All Cause Mortality.

Figure 4.

ROC Curve Comparison Between LAR and PESI Models.

Figure 5.

Forest Plot for Subgroup Analysis of the Relationship Between 28-d All Cause Mortality and LAR.