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. 2025 Aug 5;13(8):e70766.
doi: 10.1002/ccr3.70766. eCollection 2025 Aug.

"Testicular Torsion in a Child With CPT-1 Deficiency and History of Viral Myositis: Anesthesia Considerations"

Samuel Grant Volpe  1 , Aariya Srinivasan  1   2 , Sabry Ayad  1   2   3
Affiliations

"Testicular Torsion in a Child With CPT-1 Deficiency and History of Viral Myositis: Anesthesia Considerations"

Samuel Grant Volpe et al. Clin Case Rep. .

Abstract

Tailored anesthetic management is crucial for pediatric patients with inborn metabolic disorders like CPT-1 deficiency and conditions, such as viral myositis. Avoiding inhalational anesthetics and succinylcholine, using glucose infusion, safe anesthetics, and appropriate monitoring are essential to prevent metabolic crises and malignant hyperthermia during surgery, ensuring patient safety.

Keywords: lipid metabolism disorders; malignant hyperthermia; pediatric anesthesia; viral myositis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Schematic of the carnitine shuttle system in mitochondrial fatty acid oxidation.CPT‐1 deficiency blocks conversion of acyl‐CoA to acylcarnitine, preventing fatty acid entry into mitochondria.
See this image and copyright information in PMC

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References

    1. Lindner M., Hoffmann G. F., and Matern D., “Newborn Screening for Disorders of Fatty‐Acid Oxidation: Experience and Recommendations From an Expert Meeting,” Journal of Inherited Metabolic Disease 33, no. 5 (2010): 521–526, 10.1007/s10545-010-9076-8. - DOI - PubMed
    1. Lee K., Pritchard A., and Ahmad A., “Carnitine Palmitoyltransferase 1A Deficiency,” in GeneReviews, ed. Adam M. P., Feldman J., Mirzaa G. M., Pagon R. A., Wallace S. E., and Amemiya A. (University of Washington, Seattle, 2005), 1993–2025. - PubMed
    1. Adeva‐Andany M. M., Carneiro‐Freire N., Seco‐Filgueira M., Fernández‐Fernández C., and Mouriño‐Bayolo D., “Mitochondrial β‐Oxidation of Saturated Fatty Acids in Humans,” Mitochondrion 46 (2019): 73–90, 10.1016/j.mito.2018.02.009. - DOI - PubMed
    1. Bonnefont J. P., Demaugre F., Prip‐Buus C., et al., “Carnitine Palmitoyltransferase Deficiencies,” Molecular Genetics and Metabolism 68, no. 4 (1999): 424–440, 10.1006/mgme.1999.2938. - DOI - PubMed
    1. Arrab R., Benchehab Y., Alaammari I., and Dini N., “Benign Acute Myositis in Children: A Case Series,” Cureus 16, no. 11 (2024): e73303, 10.7759/cureus.73303. - DOI - PMC - PubMed

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