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. 2025 Jul 29;14(3):191-203.
doi: 10.7762/cnr.2025.14.3.191. eCollection 2025 Jul.

Effects of Replacing Skipped Meals With Oral Nutritional Supplement on Nutritional Status and Physical Function in Older Adults

Jiyeon Lee  1 , Seong Ah Cho  1 , Seoyoon Choi  2 , Eunbi Han  2 , Hyeri Shin  3 , Yoo Kyoung Park  1
Affiliations

Effects of Replacing Skipped Meals With Oral Nutritional Supplement on Nutritional Status and Physical Function in Older Adults

Jiyeon Lee et al. Clin Nutr Res. .

Abstract

This study evaluated the effects of replacing skipped meals with oral nutritional supplements (ONS) on the nutritional status and functional health of older adults. A total of 29 participants aged ≥ 65 years who regularly skipped at least one meal per day were included in this single-arm study. For 8 weeks, participants consumed two packs of ONS daily (150 mL each, providing 400 kcal and 18 g of protein) as a substitute for skipped meals. Nutritional status, nutrient intake, body composition, and physical function were assessed before and after the intervention. The Nutrition Quotient for the Elderly score significantly increased from 58.97 to 63.62 (p = 0.014). Total nutrient intake, including ONS, significantly improved compared with baseline (p < 0.01). Body weight and body mass index increased significantly from 58.87 to 59.47 kg (p = 0.028) and from 23.9 to 24.18 kg/m2 (p = 0.016), respectively. Calf circumference decreased significantly from 34.1 to 33.39 cm (p = 0.010). Physical function, assessed using the Short Physical Performance Battery, showed significant improvement (p = 0.003). In conclusion, replacing skipped meals with ONS may enhance nutritional status and support functional health in older adults.

Trial registration: Clinical Research Information Service Identifier: KCT0010184.

Keywords: Aged; Dietary supplements; Energy intake; Malnutrition.

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Conflict of interest statement

Conflict of Interest: Choi S and Han E are employed by Korea Medical Foods and were involved in the delivery of the oral nutritional supplement used in this study. The other authors declare no conflicts of interest. This study received product support from Korea Medical Foods; however, the company had no role in the study design, data collection and analysis, manuscript preparation, or the decision to submit the article for publication.

Figures

Figure 1
Figure 1. Flowchart of the study process.
M, male; F, female.
Figure 2
Figure 2. Changes in SPPB scores from baseline to week 8.
(A) Balance: 3.31 ± 0.81 to 3.76 ± 0.51 (Δ 0.45 ± 0.78, p = 0.008). (B) Gait speed: 3.96 ± 0.78 to 3.41 ± 0.61 (Δ −0.56 ± 0.88, p = 0.002). (C) Sit to stand: 9.83 ± 2.82 to 8.32 ± 1.85 (Δ −1.51 ± 2.96, p = 0.008). (D) SPPB score: 10.83 ± 1.28 to 11.62 ± 0.73 (Δ 0.79 ± 1.32, p = 0.003). Box plots show median (line inside the box), interquartile range (box), and minimum and maximum values (whiskers). SPPB, Short Physical Performance Battery.
See this image and copyright information in PMC

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