Improving Alzheimer's disease immunotherapy

Mengen Xing¹, Weihong Song^{1

2}

Affiliations

¹ Center for Geriatric Medicine, International Center for Alzheimer's Research, Prevention and Treatment, The First Affiliated Hospital and Oujiang Laboratory; Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Wenzhou Medical University, Wenzhou, Zhejiang, China.
² State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Comment

Mengen Xing et al. Science. 2025.

. 2025 Aug 7;389(6760):571-572.

doi: 10.1126/science.adz8959. Epub 2025 Aug 7.

Mengen Xing¹, Weihong Song^{1

2}

¹ Center for Geriatric Medicine, International Center for Alzheimer's Research, Prevention and Treatment, The First Affiliated Hospital and Oujiang Laboratory; Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Wenzhou Medical University, Wenzhou, Zhejiang, China.
² State Key Laboratory of Macromolecular Drugs and Large-scale Preparation, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Abstract

A modified antibody targeting amyloid-β reduces adverse events and increases efficacy in a mouse model.

Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Pizzo ME, Plowey ED, Khoury N, Kwan W, Abettan J, DeVos SL, Discenza CB, Earr T, Joy D, Lye-Barthel M, Roche E, Chan D, Dugas JC, Gadkar K, Hamann S, Meisner R, Sebalusky J, Silva Amaral AC, Becerra I, Chau R, Chow J, Clemens AJ, Dennis MS, Duque J, Fusaro L, Getz JA, Kariolis MS, Kim DJ, Lechtenberg KJ, Leung AW, Moshkforoush A, Nguyen HN, Ojo ES, Thomsen ER, Torres VO, Sanchez PE, Shan L, Silverman AP, Sweeney ZK, Solanoy H, Tong R, Calvert ME, Watts RJ, Thorne RG, Weinreb PH, Walsh DM, Lewcock JW, Bussiere T, Zuchero YJY. Pizzo ME, et al. Science. 2025 Aug 7;389(6760):eads3204. doi: 10.1126/science.ads3204. Epub 2025 Aug 7. Science. 2025. PMID: 40773560