Opening the gateway to food-induced anaphylaxis

Tamara T Haque^{1

2}, Mark H Kaplan^{1

2}

Affiliations

¹ Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
² Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.

Comment

Tamara T Haque et al. Science. 2025.

. 2025 Aug 7;389(6760):573-574.

doi: 10.1126/science.adz6439. Epub 2025 Aug 7.

Tamara T Haque^{1

2}, Mark H Kaplan^{1

2}

¹ Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
² Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA.

Abstract

Cysteinyl leukotrienes are important drivers of the anaphylactic response to ingested food antigens.

Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice.
Hoyt LR, Liu E, Olson EC, Jacobsen DR, Siniscalco ER, Krier-Burris RA, Greenfield KG, McBride CD, Alfajaro MM, Amat JAR, Zhao Z, Xu L, Philip V, Verma A, Fourati S, Senger DL, Zhang L, Bunyavanich S, Glass SE, Coffey RJ, Wilen CB, Williams A, Eisenbarth SC. Hoyt LR, et al. Science. 2025 Aug 7;389(6760):eadp0240. doi: 10.1126/science.adp0240. Epub 2025 Aug 7. Science. 2025. PMID: 40773557