Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Aug 7;33(9):762.
doi: 10.1007/s00520-025-09821-y.

Prevalence and associated factors of cognitive frailty in older patients with lung cancer undergoing chemotherapy: a cross-sectional study

Fengping Zheng  1 , Yawen Zhao  1 , Xiaomei Ren  1 , Xiaoqian Lan  2 , Wentao Peng  3
Affiliations

Prevalence and associated factors of cognitive frailty in older patients with lung cancer undergoing chemotherapy: a cross-sectional study

Fengping Zheng et al. Support Care Cancer. .

Abstract

Purpose: To examine the prevalence of cognitive frailty and identify its influencing factors among in older patients with lung cancer undergoing chemotherapy.

Methods: A cross-sectional study was conducted between January and August 2024 among 304 older patients with lung cancer undergoing chemotherapy at a tertiary hospital in Chengdu, China. Data were collected using a general information questionnaire, the FRAIL Scale, the Mini-Mental State Examination (MMSE), the Hospital Anxiety and Depression Scale (HADS), and the Nutritional Risk Screening 2002 (NRS 2002). Binary logistic regression was performed to identify independent risk factors associated with cognitive frailty.

Results: A total of 304 older patients with lung cancer undergoing chemotherapy finished the investigation. The prevalence of cognitive frailty was 26.3% (80/304). In the initial phase of analysis, 13 independent variables were selected from 23 candidate variables through univariate analysis. Subsequent binary logistic regression analysis revealed that age, monthly household income per capita, employment status, health insurance type, cancer stage, anxiety, depression, nutritional risk, and daily exercise duration were independently associated with cognitive frailty.

Conclusion: The prevalence of cognitive frailty is high among older patients with lung cancer undergoing chemotherapy and is influenced by multiple factors. Therefore, screening for cognitive frailty should be considered in clinical practice, with particular focus on elderly patients, those with low income, and those in advanced stages of the disease. It is crucial to take into account the patients' physiological, psychological, and behavioral factors when designing and implementing multimodal, individualized intervention strategies, aiming to effectively prevent and alleviate cognitive frailty.

Keywords: Chemotherapy; Cognitive frailty; Lung cancer; Older patients.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval: Approval was obtained from the ethics committee of West China Hospital of Sichuan University. The procedures used in this study adhere to the tenets of the Declaration of Helsinki. Consent to participate: Informed consent was obtained from all individual participants included in the study. Competing interests: The authors have no relevant financial or non-financial interests to disclose.

Similar articles

See all similar articles

References

    1. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74:229–263. https://doi.org/10.3322/caac.21834 - DOI - PubMed
    1. Fang Y, Li Z, Chen H, Zhang T, Yin X, Man J, Yang X, Lu M (2023) Burden of lung cancer along with attributable risk factors in China from 1990 to 2019, and projections until 2030. J Cancer Res Clin Oncol 149:3209–3218. https://doi.org/10.1007/s00432-022-04217-5 - DOI - PubMed
    1. Li C, Lei S, Ding L, Xu Y, Wu X, Wang H, Zhang Z, Gao T, Zhang Y, Li L (2023) Global burden and trends of lung cancer incidence and mortality. Chin Med J 136:1583–1590. https://doi.org/10.1097/cm9.0000000000002529 - DOI - PubMed - PMC
    1. Zheng R, Zhang S, Wang S, Chen R, Sun K, Zeng H, Li L, Wei W, He J (2022) Lung cancer incidence and mortality in China: updated statistics and an overview of temporal trends from 2000 to 2016. J Natl Cancer Cent 2:139–147. https://doi.org/10.1016/j.jncc.2022.07.004 - DOI - PubMed - PMC
    1. Zeng H, Zheng R, Sun K, Zhou M, Wang S, Li L, Chen R, Han B, Liu M, Zhou J, Xu M, Wang L, Yin P, Wang B, You J, Wu J, Wei W, He J (2024) Cancer survival statistics in China 2019–2021: a multicenter, population-based study. J Natl Cancer Center 4:203–213. https://doi.org/10.1016/j.jncc.2024.06.005 - DOI

MeSH terms

Substances

LinkOut - more resources