Correction: Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients

Tzu-Chun Cheng¹, Mien-Chie Hung^{2

3}, Lu-Hai Wang⁴, Shih-Hsin Tu^{5

6}, Chih-Hsiung Wu^{5

6}, Yun Yen⁷, Chi-Long Chen^{8

9}, Jacqueline Whang-Peng⁷, Wen-Jui Lee¹, You-Cheng Liao¹⁰, Yu-Ching Lee⁷, Min-Hsiung Pan¹¹, Hui-Kuan Lin¹², Huey-En Tzeng^{13

14}, Peixuan Guo¹⁵, Cheng-Ying Chu^{7

16}, Li-Ching Chen¹⁷, Yuan-Soon Ho¹⁸

Affiliations

¹ Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan.
² Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.
³ Department of Biotechnology, Asia University, Taichung, Taiwan.
⁴ Institute of Integrated Medicine and Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.
⁵ Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁶ Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan.
⁷ TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.
⁸ Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁹ Department of Pathology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
¹⁰ Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
¹¹ Institute of Food Sciences and Technology, National Taiwan University, Taipei, Taiwan.
¹² Department of Pathology, Duke University Medical Center, Duke University School of Medicine, Durham, NC, 27710, USA.
¹³ Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan.
¹⁴ Department of Post-Baccalaureate Medicine, College of Medicine, National Chung-Hsing University, Taichung, Taiwan.
¹⁵ Center for RNA Nanobiotechnology and Nanomedicine, College of Pharmacy, College of Medicine, Dorothy M. Davis Heart and Lung Research Institute, and James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
¹⁶ CRISPR Gene Targeting Core, Taipei Medical University, Taipei, 110, Taiwan.
¹⁷ Department of Biological Science & Technology, College of Life Sciences, China Medical University, Taichung, Taiwan. lcchen@cmu.edu.tw.
¹⁸ Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan. hoyuansn@cmu.edu.tw.

PMID: 40775794
PMCID: PMC12330129
DOI: 10.1186/s40364-025-00819-6

Published Erratum

Correction: Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients

Tzu-Chun Cheng et al. Biomark Res. 2025.

. 2025 Aug 7;13(1):100.

doi: 10.1186/s40364-025-00819-6.

Authors

Affiliations

¹ Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan.
² Graduate Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, Research Center for Cancer Biology, Cancer Biology and Precision Therapeutics Center, and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.
³ Department of Biotechnology, Asia University, Taichung, Taiwan.
⁴ Institute of Integrated Medicine and Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.
⁵ Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁶ Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan.
⁷ TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan.
⁸ Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
⁹ Department of Pathology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
¹⁰ Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
¹¹ Institute of Food Sciences and Technology, National Taiwan University, Taipei, Taiwan.
¹² Department of Pathology, Duke University Medical Center, Duke University School of Medicine, Durham, NC, 27710, USA.
¹³ Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan.
¹⁴ Department of Post-Baccalaureate Medicine, College of Medicine, National Chung-Hsing University, Taichung, Taiwan.
¹⁵ Center for RNA Nanobiotechnology and Nanomedicine, College of Pharmacy, College of Medicine, Dorothy M. Davis Heart and Lung Research Institute, and James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
¹⁶ CRISPR Gene Targeting Core, Taipei Medical University, Taipei, 110, Taiwan.
¹⁷ Department of Biological Science & Technology, College of Life Sciences, China Medical University, Taichung, Taiwan. lcchen@cmu.edu.tw.
¹⁸ Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan. hoyuansn@cmu.edu.tw.

PMID: 40775794
PMCID: PMC12330129
DOI: 10.1186/s40364-025-00819-6

No abstract available

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Figures

**Fig. 5**
The molecular mechanism by which HNMT enhances BC cell sensitivity to anti-HER2 targeted drugs. The molecular mechanism underlying HER2-induced oncogenesis involves a series of intricate steps. A In this study, EGF (100 ng/mL) was added to SKBR3 cancer cells, and the kinetic process of complex formation was observed. (a) Firstly, in response to EGF activation of HER2 signaling, cytoplasmic HNMT translocates to the cell membrane, and the HNMT/HER2 complex can be observed on the cell membrane within approximately 10–20 min (red arrows). Following this, (b-c) HNMT facilitates the recruitment of γ-secretase, which occurs around 30 min. Subsequently, the γ-secretase (PS1/PS2) complex forms with HER2, taking approximately 30–60 min. During this process, the HER2-ICD enters the cytoplasm (white arrowhead). (d-e) After 60 min of EGF treatment, it is observable that the HNMT/HER2-ICD complex enters the cell nucleus (yellow arrow). It binds to the HER2 promoter, inducing the upregulation of HER2 and HER2-associated oncogenic proteins. The newly synthesized HER2 protein subsequently translocates to the cell membrane, contributing to the manifestation of an H-cell phenotype and enhancing the binding of therapeutic agents such as trastuzumab or T-Dxd in HER2+cells. B Based on the above results, the molecular mechanism of HNMT involvement in HER2 gene activation can be simplifed, as shown in the schematic diagram

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Erratum for

Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients.
Cheng TC, Hung MC, Wang LH, Tu SH, Wu CH, Yen Y, Chen CL, Whang-Peng J, Lee WJ, Liao YC, Lee YC, Pan MH, Lin HK, Tzeng HE, Guo P, Chu CY, Chen LC, Ho YS. Cheng TC, et al. Biomark Res. 2025 Jan 9;13(1):7. doi: 10.1186/s40364-024-00715-5. Biomark Res. 2025. PMID: 39789599 Free PMC article.

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Correction: Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients

Affiliations

Correction: Histamine N-methyltransferase (HNMT) as a potential auxiliary biomarker for predicting adaptability to anti-HER2 drug treatment in breast cancer patients

Authors

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Erratum for

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