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Review
. 2025 Jul 7;17(7):e87479.
doi: 10.7759/cureus.87479. eCollection 2025 Jul.

PulseRider Aneurysm Neck Reconstructive Device Versus Other Treatments in Patients With Wide-Neck Bifurcation Aneurysms: A Systematic Review

Mariana Olvera Morales  1 , Diego Santillán Alcántar  2 , Jose R Flores Valdés  3 , Mariana Del Rio Rocha  1 , Mark Reyes Anaya  1 , Mauricio Montelongo Quevedo  1 , Karla Y Bujdud Rodríguez  4 , Gilberto Granados García  5 , Luis C Lora Ponce  6 , Sergio A Villar López  1 , Juan P Navarro Garcia de Llano  7
Affiliations
Review

PulseRider Aneurysm Neck Reconstructive Device Versus Other Treatments in Patients With Wide-Neck Bifurcation Aneurysms: A Systematic Review

Mariana Olvera Morales et al. Cureus. .

Abstract

Wide-neck bifurcation aneurysms (WNBA) are challenging to treat both surgically and endovascularly due to their complex anatomy. The FDA-approved PulseRider Aneurysm Neck Reconstructive Device (PRANRD; Cerenovus, Johnson & Johnson, Irvine, CA, USA) offers a novel endovascular treatment option; however, comparative data on its safety and efficacy remain limited. This review compares PRANRD with other treatment modalities for unruptured WNBA. A search of multiple databases identified 51 articles, of which three met the inclusion criteria, comprising two cohort studies and one case series, for a total of 134 patients treated with PRANRD. The device achieved complete angiographic occlusion in most cases with low complication rates. Compared to Y-stenting, PRANRD-assisted coiling demonstrated similar immediate occlusion rates but lower complete occlusion rates at six months. No procedure-related mortality was reported. However, long-term follow-up and randomized controlled trials are still required. PRANRD appears to be a promising alternative for treating WNBA, offering high occlusion rates and a favorable safety profile. Further research is necessary to confirm its long-term efficacy and safety.

Keywords: aneurysm; bifurcated; equipment; neck; supplies; wide neck.

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Conflict of interest statement

Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. PRISMA flowchart
Fifty-one records were screened. Records were identified, screened, excluded, sought for retrieval, assessed for eligibility, and excluded for the following reasons: five articles had an incorrect study design, one article had a wrong publication type, and one article had a wrong outcome [14]. PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses
See this image and copyright information in PMC

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