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. 2024 Sep;24(3):63-68.
doi: 10.4314/ahs.v24i3.9.

The predictive value of PCT, SP-D and 8-iso-PGF2 α for the development of severe pneumonia in children

Guiying Zhang  1 , Yang Hu  1 , Bo Huang  1 , Hongliang Gao  1 , Mengsha Zhu  1
Affiliations

The predictive value of PCT, SP-D and 8-iso-PGF2 α for the development of severe pneumonia in children

Guiying Zhang et al. Afr Health Sci. 2024 Sep.

Abstract

Background: To investigate the predictive value of predictive value of procalcitonin (PCT), 8-iso-prostaglandin F2α (8-iso-PGF2α) and pulmonary surfactant-associated protein D (SP-D) for the development of severe pneumonia in children.

Methodology: Children with severe pneumonia were selected as the pneumonia group, and children with non-pulmonary respiratory diseases were selected as the control group. PCT, 8-iso-PGF2α, and SP-D were compared between the pneumonia group and the control group at admission; PCT, 8-iso-PGF2α, SP-D, and Acute Physiology and Chronic Health Evaluation (APACHE-II), Pediatric Critical Illness Score (PCIS) and Clinical Pulmonary Infection Score (CPIS) scores were compared between children with severe pneumonia with different pathogen infection types and different prognostic outcomes; and the correlation between APACHE-II, CPIS, and PCIS scores and PCT, 8-iso-PGF2α, and SP-D levels was analysed in children with severe pneumonia.

Results: PCT, 8-iso-PGF2α and SP-D in pneumonia group were higher than those in control group. PCT, 8-iso-PGF2α, SP-D, APACHE-II, CPIS, and PCIS were lower in good prognosis children than in poor prognosis children. APACHE-II, CPIS, and PCIS scores were positively correlated with PCT, 8-iso-PGF2α, and SP-D levels in children with severe pneumonia (P < 0.05).

Conclusion: PCT, SP-D and 8-iso-PGF2α levels relate to pathogen type, illness severity and prognosis in children with severe pneumonia. They can aiding early evaluation.

Keywords: 8-isoprostane F2α; disease assessment; procalcitonin; pulmonary surfactant-associated protein D; severe pneumonia in children.

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Conflict of interest statement

The authors declared no conflict of interest.

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