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. 1985;110(3):221-4.
doi: 10.1007/BF00399277.

Reversal of natural resistance to bouvardin (NSC 259968) in sarcoma 180 cells in vitro and in vivo by verapamil

M P Chitnis, R S Menon, V S Basrur, M K Adwankar, K Satyamoorthy

Reversal of natural resistance to bouvardin (NSC 259968) in sarcoma 180 cells in vitro and in vivo by verapamil

M P Chitnis et al. J Cancer Res Clin Oncol. 1985.

Abstract

Reversal of natural resistance to bouvardin (NSC 259968) has been attained in vitro and in vivo, by the calcium influx blocker verapamil in sarcoma 180 cells insensitive to bouvardin. Verapamil increased the in vitro lethality of the tumor cells following exposure with cells for 1 and 3 h as a result of the cytotoxic effect of bouvardin. Similar results were observed in vivo when the tumor cells were exposed to verapamil and then treated with bouvardin, showing a significant percent increase in the lifespan to 30% and 45%. This suggested that this calcium channel blocker had interacted with tumor cell membrane to modulate the response of the cells, and make them more amenable to the drug action.

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References

    1. Adwankar MK, Chitnis MP (1983) Alteration in natural resistance of sarcoma 180 tumor to Bouvardin (NSC 259968) following hyperthermia. Tumori 69:309–312 - PubMed
    1. Carter SK (1975) Adriamycin-a review. J Natl Cancer Inst 55:1265–1274 - PubMed
    1. Chervincsky DS, Wang JJ (1976) Uptake of adriamycin and daunomycin in L1210 and human leukemia cells: a comparative study. J Med 7:63–79 - PubMed
    1. Chitnis MP, Johnson RK (1978) Biochemical parameters of resistance of an adriamycin-resistant subline of P388 leukemia to emetine, an inhibitor of protein synthesis. J Natl Cancer Inst 60:1049–1054 - PubMed
    1. Chitnis MP, Alate AD, Menon RS (1981) Effect of Bouvardin (NSC 259968) on the growth characteristics and nucleic acids and protein synthesis profiles of P388 leukemia cells. Chemotherapy 27:126–130 - PubMed

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