Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985;110(3):244-6.
doi: 10.1007/BF00399282.

Influence of experimental diets on hepatic glutathione levels in rats with methylnitrosourea-induced mammary carcinoma

M Aksoy, E Frei, M R Berger

Influence of experimental diets on hepatic glutathione levels in rats with methylnitrosourea-induced mammary carcinoma

M Aksoy et al. J Cancer Res Clin Oncol. 1985.

Abstract

Mammary tumor development induced by methylnitrosourea in female Sprague-Dawley rats had no significant effect on hepatic glutathione levels. If the diets of methylnitrosourea-treated animals were supplemented with vitamin A and E an increased hepatic glutathione level was observed initially. A high fat diet (21% per weight) supplemented with the two vitamins led to a decreased hepatic glutathione level 2 months after tumor induction. Advanced tumor development under any of the diets tested had no effect on hepatic glutathione.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Aksoy M (1984) Beslenmenin Kanser Oluşumundaki Rolü. In: Beslenme ve Kanser (nutrition and cancer). M Aksoy (ed) Çag Mat, Ankara, 13–68
    1. Bertram B, Frei E, Scherf HR, Schuhmacher J, Tacchi AM, Wiessler M (1985) Influence of a prolonged treatment with disulfiram and D-penicillamine on nitrosodiethylamine induced biological and biochemical effects in rats. J Cancer Res Clin Oncol 109:9–15 - PMC - PubMed
    1. Byers T, Graham S (1984) The epidemiology of diet and cancer. Adv Cancer Res 41:1–69 - PubMed
    1. Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70–77 - PubMed
    1. Larsson A, Orrenius S, Holmgren A, Mannervik B (eds) (1983) Functions of glutathione: biochemical, physiological, toxicological and clinical aspects. Raven Press, New York, pp 9–10, 40, 131–132, 256–258, 320–322

LinkOut - more resources