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. 1985;110(3):244-6.
doi: 10.1007/BF00399282.

Influence of experimental diets on hepatic glutathione levels in rats with methylnitrosourea-induced mammary carcinoma

M Aksoy, E Frei, M R Berger

Influence of experimental diets on hepatic glutathione levels in rats with methylnitrosourea-induced mammary carcinoma

M Aksoy et al. J Cancer Res Clin Oncol. 1985.

Abstract

Mammary tumor development induced by methylnitrosourea in female Sprague-Dawley rats had no significant effect on hepatic glutathione levels. If the diets of methylnitrosourea-treated animals were supplemented with vitamin A and E an increased hepatic glutathione level was observed initially. A high fat diet (21% per weight) supplemented with the two vitamins led to a decreased hepatic glutathione level 2 months after tumor induction. Advanced tumor development under any of the diets tested had no effect on hepatic glutathione.

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