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. 2025 Aug 8;21(8):e1013351.
doi: 10.1371/journal.ppat.1013351. eCollection 2025 Aug.

Host-induced climate change: Carbon dioxide tolerance as a Cryptococcus neoformans virulence trait

Emma E Blackburn  1 , Laura C Ristow  2 , Xiaorong Lin  1   3 , Damian J Krysan  2   4
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Host-induced climate change: Carbon dioxide tolerance as a Cryptococcus neoformans virulence trait

Emma E Blackburn et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Carbon dioxide tolerance as a virulence trait in Cryptococcus neoformans.
A. Schematic summarizing the effects of CO2 on C. neoformans cellular physiology and the signaling pathways that positively (green box) and negatively (red box) CO2 tolerance. Carbonic anhydrase (CAN). B. The competitive fitness of environmental and clinical isolates from the indicated C. neoformans clades in 5% CO2 in buffered RPMI medium at 37°C relative to the reference strain H99; data are from reference [6].
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