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. 1985 Oct;22(4):664-5.
doi: 10.1128/jcm.22.4.664-665.1985.

Inhibitory effect of glucocorticoid hormones on the growth of Inoue-Melnick virus

Y K Inoue, Y Nishibe, J L Melnick, E Seidel, S S Wang

Inhibitory effect of glucocorticoid hormones on the growth of Inoue-Melnick virus

Y K Inoue et al. J Clin Microbiol. 1985 Oct.

Abstract

Glucocorticoid hormones inhibited the early stage of propagation of Inoue-Melnick virus in a dose-dependent manner in human diploid cell cultures. Prednisolone and hydrocortisone achieved complete inhibition of replication of the three Inoue-Melnick virus serotypes at concentrations of 0.2 X 10(-4) and 10(-5) M, respectively; strong inhibition was found even at 10(-5) and 10(-6) M, respectively. The steroid hormones did not show a direct effect on the virus.

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