Bismuth based nanomaterials: Design, synthesis and applications in tumor synergistic therapy

Qiupeng Zhang¹, Jie Tu¹, Yuqin Jiang², Huihui Wang¹, Weixian Xue¹, Chunyao Dong¹, Ruizhuo Ouyang³, Yuqing Miao⁴

Affiliations

¹ Institute of Bismuth and Rhenium Science, University of Shanghai for Science and Technology, Shanghai 200093, China; USST-UH International Joint Laboratory for Tumor Diagnosis and Energy Treatment, University of Shanghai for Science and Technology, Shanghai 200093, China.
² Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Engineering Research Centre of Chiral Hydroxyl Pharmaceutical, Henan Engineering Laboratory of Chemical Pharmaceutical and Biomedical Materials, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China.
³ Institute of Bismuth and Rhenium Science, University of Shanghai for Science and Technology, Shanghai 200093, China; USST-UH International Joint Laboratory for Tumor Diagnosis and Energy Treatment, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address: ouyangrz@usst.edu.cn.
⁴ Institute of Bismuth and Rhenium Science, University of Shanghai for Science and Technology, Shanghai 200093, China; USST-UH International Joint Laboratory for Tumor Diagnosis and Energy Treatment, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address: yqmiao@usst.edu.cn.

PMID: 40779966
DOI: 10.1016/j.colsurfb.2025.114992

Review

Bismuth based nanomaterials: Design, synthesis and applications in tumor synergistic therapy

Qiupeng Zhang et al. Colloids Surf B Biointerfaces. 2025 Dec.

. 2025 Dec;256(Pt 1):114992.

doi: 10.1016/j.colsurfb.2025.114992. Epub 2025 Aug 5.

Authors

Qiupeng Zhang¹, Jie Tu¹, Yuqin Jiang², Huihui Wang¹, Weixian Xue¹, Chunyao Dong¹, Ruizhuo Ouyang³, Yuqing Miao⁴

Affiliations

¹ Institute of Bismuth and Rhenium Science, University of Shanghai for Science and Technology, Shanghai 200093, China; USST-UH International Joint Laboratory for Tumor Diagnosis and Energy Treatment, University of Shanghai for Science and Technology, Shanghai 200093, China.
² Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Engineering Research Centre of Chiral Hydroxyl Pharmaceutical, Henan Engineering Laboratory of Chemical Pharmaceutical and Biomedical Materials, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China.
³ Institute of Bismuth and Rhenium Science, University of Shanghai for Science and Technology, Shanghai 200093, China; USST-UH International Joint Laboratory for Tumor Diagnosis and Energy Treatment, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address: ouyangrz@usst.edu.cn.
⁴ Institute of Bismuth and Rhenium Science, University of Shanghai for Science and Technology, Shanghai 200093, China; USST-UH International Joint Laboratory for Tumor Diagnosis and Energy Treatment, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address: yqmiao@usst.edu.cn.

PMID: 40779966
DOI: 10.1016/j.colsurfb.2025.114992

Abstract

With the rapid development of nanomedicine, nanomaterials (NMs) have been used in clinical medicine to improve treatment efficiency. Bismuth-based nanomaterials(BNMs) are promising candidates for cancer diagnosis and therapy because of their good biocompatibility, low cost, high X-ray attenuation and near infrared absorption coefficient. The traditional therapy mode is relatively single, and the treatment effect is not significantly improved. Therefore, the combination of traditional treatment and emerging treatment not only has high lethality to tumor cell, but also makes up for their shortcomings. This review summarizes the latest research on BNMs in tumor therapy in recent years, including: the design and preparation of BNMs, the synergy of multiple treatment technologies, and the biosafety of nanomaterials. In the end, the inspiration and reference for the study of Bi-based multifunctional nano-platforms were provided for clinical use.

Keywords: BNMs; Biosafety; Synergistic therapy; Tumor therapy.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Bismuth based nanomaterials: Design, synthesis and applications in tumor synergistic therapy

Affiliations

Bismuth based nanomaterials: Design, synthesis and applications in tumor synergistic therapy

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical