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. 2025 Aug 7;188(16):4175-4177.
doi: 10.1016/j.cell.2025.07.008.

Arrestins and opioid-independent analgesia

Olena Didenko  1 , John N Wood  2
Affiliations

Arrestins and opioid-independent analgesia

Olena Didenko et al. Cell. .

Abstract

In this issue of Cell, Ji and colleagues describe the development of SBI-810, a β-arrestin-biased modulator of neurotensin receptor 1 (NTSR1). This compound provides potent analgesia in rodent models of acute and chronic pain without side effects. This study highlights the therapeutic potential of targeting arrestin-biased GPCR signaling for non-opioid pain management.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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