cGAS: a novel therapeutic target in systemic sclerosis-associated interstitial lung disease

Affiliations

¹ Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
² Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA jherazomaya@usf.edu.

Editorial

Theodoros Karampitsakos et al. Eur Respir J. 2025.

. 2025 Aug 8;66(2):2500835.

doi: 10.1183/13993003.00835-2025. Print 2025 Aug.

¹ Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
² Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA jherazomaya@usf.edu.

No abstract available

Conflict of interest statement

Conflict of interest: The authors have no potential conflicts of interest to disclose.

Cyclic GMP-AMP synthase expression is enhanced in systemic sclerosis-associated interstitial lung disease and stimulates inflammatory myofibroblast activation.
Yu S, Hu B, Sun Y, Peng XY, Lee CJ, Woo S, McGovern J, Zielonka J, Saber T, Ghincea A, Gandhi S, Walia A, Pivarnik T, Ishikawa G, Shao S, Sun H, Gunes BI, Kujawski S, Perez S, Odell W, Hinchcliff M, Varga J, Feghali-Bostwick C, Sauler M, Gomez JL, Ryu C, Herzog EL. Yu S, et al. Eur Respir J. 2025 Aug 8;66(2):2401564. doi: 10.1183/13993003.01564-2024. Print 2025 Aug. Eur Respir J. 2025. PMID: 40374521 Free PMC article.