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Review
. 2025 Sep:313:114635.
doi: 10.1016/j.ejogrb.2025.114635. Epub 2025 Aug 7.

Controversies in the diagnosis and management of preterm prelabour rupture of the membranes

Megan Hall  1 , Megan Sharps  2 , Lily Wright  2 , Adam Stevens  2 , Andrew Shennan  1 , Lisa Story  3
Affiliations
Review

Controversies in the diagnosis and management of preterm prelabour rupture of the membranes

Megan Hall et al. Eur J Obstet Gynecol Reprod Biol. 2025 Sep.

Abstract

Preterm prelabour rupture of the membranes precedes around 30% of spontaneous preterm births. As well as its associations with complications of prematurity, it is additionally associated with pulmonary hypoplasia as well as increased rates of maternal sepsis and its sequelae. However, all stages of clinical management remain a challenge: from diagnosis, through to management and timing of delivery. This review discusses some of the major challenges clinicians face when caring for women with preterm prelabour rupture of the membranes.

Keywords: Chorioamnionitis; Placental dysfunction; Preterm birth; Preterm prelabour rupture of the membranes.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Lisa Story reports financial support was provided by King’s College London University and Guy’s and St Thomas’ NHS Foundation Trust. Lisa Story reports financial support was provided by National Institute for Health and Care Research. Lisa Story reports a relationship with National Institute for Health and Care Research that includes: funding grants. Lisa Story has given an invited talk at an event organised by LD Collins. Stipend paid to the university KCL not personally. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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