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Review
. 2025 Aug 8;6(8):100771.
doi: 10.1016/j.medj.2025.100771.

Alzheimer's disease: Clinical trials to watch

Marwan Noel Sabbagh  1 , Jessica Kennedy  2 , Jad Majeed  3 , Boris Decourt  2
Affiliations
Review

Alzheimer's disease: Clinical trials to watch

Marwan Noel Sabbagh et al. Med. .

Abstract

Second-generation anti-amyloid therapies (ATTs) offer new options for early Alzheimer's disease treatment, but with modest efficacy and documented adverse events. Here we highlight several ongoing clinical trials, aiming to develop therapeutic agents with higher efficacy and better safety profiles including third-generation ATTs, aggregation inhibitors, Sigma-1 receptor agonists, anti-tau antisense oligonucleotides, and GLP-1 receptor agonists.

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Conflict of interest statement

Declaration of interests Dr. Sabbagh discloses that he consults for Alzheon, Athira, Roche-Genentech, Synaptogenix, Novo Nordisk, Signant Health, Eisai, GSK, Abbvie, Lilly, and Neurotherapia. Dr. Decourt is a consultant to Lighthouse Therapeutics. Jessica Kennedy and Jad Majeed have no disclosures to report.

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