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Review
. 2025 Aug 9;192(9):572.
doi: 10.1007/s00604-025-07443-z.

Advances in molecularly imprinted polymers for clinical biomarker detection (2021-2025)

Shiying Chen #  1 , Jianhua Sun #  2 , Yuzhen Li  1 , Aiqi Qiao  1 , Yilin Hou  1 , Lei Jin  3 , Hao Wang  4
Affiliations
Review

Advances in molecularly imprinted polymers for clinical biomarker detection (2021-2025)

Shiying Chen et al. Mikrochim Acta. .

Abstract

The growing demand for early and precise disease diagnosis has made biomarker detection a vital component of modern precision medicine. However, conventional detection methods often struggle with cost, scalability, and robustness in complex biological samples. Molecularly imprinted polymers (MIPs), synthetic biorecognition materials that mimic natural molecular recognition mechanisms, have emerged as a transformative solution and gained increasing attention from the scientific community. MIPs are created by forming specific recognition sites within the polymer matrix using target molecules as templates. These sites enable MIPs to recognize the target molecules with high sensitivity and specificity, making them highly promising for applications in biomarker detection. The aim of this review is to comprehensively summarize the latest research on the application of MIPs in clinical diagnostic biomarker assays from 2021 to 2025, with a particular focus on (1) composition and structure of MIPs; (2) preparation methods; and (3) the use of MIPs for biomarker detection. Through an in-depth analysis of these studies, this review endeavors to provide valuable insights and guidance for future medical research and clinical applications involving MIPs.

Keywords: Biomarker; Clinical detection; Molecularly imprinted polymer.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests.

References

    1. Aronson JK, Ferner RE (2017) Biomarkers—a general review. Curr Protoc Pharmacol 76(1):1–9
    1. Zhou Y, Tao L, Qiu J, Xu J, Yang X, Zhang Y, Tian X, Guan X, Cen X, Zhao Y (2024) Tumor biomarkers for diagnosis, prognosis and targeted therapy. Signal Transduct Target Ther 9(1):132. https://doi.org/10.1038/s41392-024-01823-2 - DOI - PubMed - PMC
    1. Eroles M, Rico F (2023) Advances in mechanical biomarkers. J Mol Recognit 36(8):e3022 - PubMed
    1. Antipchik M, Reut J, Ayankojo AG, Opik A, Syritski V (2022) MIP-based electrochemical sensor for direct detection of hepatitis C virus via E2 envelope protein. Talanta 250:123737 - PubMed
    1. Ayankojo AG, Reut J, Boroznjak R, Syritski V (2025) Ruthenium oxide electrode integrated with molecularly imprinted polymer for direct electrochemical sensing of a neurotrophic factor protein. Sensor Actuat B: Chem 429:137301. https://doi.org/10.1016/j.snb.2025.137301 - DOI